An Ester-Substituted Semiconducting Polymer with Efficient Nonradiative Decay Enhances NIR-II Photoacoustic Performance for Monitoring of Tumor Growth

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Menglei Zha
  • Xiangwei Lin
  • Jen-Shyang Ni
  • Yaxi Li
  • Xun Zhang
  • Kai Li

Detail(s)

Original languageEnglish
Pages (from-to)23268-23276
Journal / PublicationAngewandte Chemie - International Edition
Volume59
Issue number51
Online published5 Sep 2020
Publication statusPublished - 14 Dec 2020

Abstract

Photoacoustic agents have been of vital importance for improving the imaging contrast and reliability against self-interference from endogenous substances. Herein, we synthesized a series of thiadiazoloquinoxaline (TQ)-based semiconducting polymers (SPs) with a broad absorption covering from NIR-I to NIR-II regions. Among them, the excited s-BDT-TQE, a repeating unit of SPs, shows a large dihedral angle and narrow adiabatic energy as well as low radiative decay, attributing to its strongly electron-deficient ester-substituted TQ-segment. In addition, its more vigorous molecular motions trigger a higher reorganization energy that further yields an efficient photoinduced nonradiative decay, which has been carefully examined and understood by theoretical calculation. Thus, BDT-TQE SP-cored nanoparticles with twisted intramolecular charge transfer (TICT) feature exhibit a high NIR-II photothermal conversion efficiency (61.6 %) and preferable PA tracking of in situ hepatic tumor growth for more than 20 days. This study highlights a unique strategy for constructing efficient NIR-II photoacoustic agents via TICT-enhanced PNRD effect, advancing their applications for in vivo bioimaging.

Research Area(s)

  • photoacoustic, photothermal conversion, reorganization energy, reversed AIE, TICT

Citation Format(s)

An Ester-Substituted Semiconducting Polymer with Efficient Nonradiative Decay Enhances NIR-II Photoacoustic Performance for Monitoring of Tumor Growth. / Zha, Menglei; Lin, Xiangwei; Ni, Jen-Shyang et al.

In: Angewandte Chemie - International Edition, Vol. 59, No. 51, 14.12.2020, p. 23268-23276.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review