An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment

Lichun Ma; Debby D. Wang; Bin Zou; Hong Yan

doi:10.1109/TCBB.2016.2568184

Author(s)

Lichun Ma
Debby D. Wang
Bin Zou
Hong Yan

Related Research Unit(s)

Department of Electrical Engineering

Detail(s)

Original language	English
Pages (from-to)	1187-1194
Journal / Publication	IEEE/ACM Transactions on Computational Biology and Bioinformatics
Volume	14
Issue number	5
Online published	12 May 2016
Publication status	Published - 1 Sept 2017

Link(s)

DOI	DOI https://doi.org/10.1109/TCBB.2016.2568184 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85032445851&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(b9155c52-eaaf-4f87-b425-4505a41aa8e3).html

Abstract

We explore the drug resistance mechanism in non-small cell lung cancer treatment by characterizing the drug-binding site of a protein mutant based on local surface and energy features. These features are transformed to an eigen-binding site space and used for drug resistance level prediction and analysis.

Research Area(s)

Epidermal growth factor receptor, non-small-cell lung carcinoma, tyrosine kinase inhibitor, gefitinib, binding free energy, binding site, alpha shape modeling

Citation Format(s)

[ RIS ] [ BibTeX ]

An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment. / Ma, Lichun; Wang, Debby D.; Zou, Bin et al.
In: IEEE/ACM Transactions on Computational Biology and Bioinformatics, Vol. 14, No. 5, 01.09.2017, p. 1187-1194.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Ma, L, Wang, DD, Zou, B & Yan, H 2017, 'An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment', IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 14, no. 5, pp. 1187-1194. https://doi.org/10.1109/TCBB.2016.2568184

Ma, L., Wang, D. D., Zou, B., & Yan, H. (2017). An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 14(5), 1187-1194. Advance online publication. https://doi.org/10.1109/TCBB.2016.2568184

Ma L, Wang DD, Zou B , Yan H. An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2017 Sept 1;14(5):1187-1194. Epub 2016 May 12. doi: 10.1109/TCBB.2016.2568184

Ma, Lichun ; Wang, Debby D. ; Zou, Bin et al. / An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment. In: IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2017 ; Vol. 14, No. 5. pp. 1187-1194.