An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

12 Scopus Citations
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Detail(s)

Original languageEnglish
Pages (from-to)1187-1194
Journal / PublicationIEEE/ACM Transactions on Computational Biology and Bioinformatics
Volume14
Issue number5
Online published12 May 2016
Publication statusPublished - 1 Sept 2017

Abstract

We explore the drug resistance mechanism in non-small cell lung cancer treatment by characterizing the drug-binding site of a protein mutant based on local surface and energy features. These features are transformed to an eigen-binding site space and used for drug resistance level prediction and analysis.

Research Area(s)

  • Epidermal growth factor receptor, non-small-cell lung carcinoma, tyrosine kinase inhibitor, gefitinib, binding free energy, binding site, alpha shape modeling

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