An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

8 Scopus Citations
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Detail(s)

Original languageEnglish
Pages (from-to)1187-1194
Journal / PublicationIEEE/ACM Transactions on Computational Biology and Bioinformatics
Volume14
Issue number5
Online published12 May 2016
Publication statusPublished - 1 Sep 2017

Abstract

We explore the drug resistance mechanism in non-small cell lung cancer treatment by characterizing the drug-binding site of a protein mutant based on local surface and energy features. These features are transformed to an eigen-binding site space and used for drug resistance level prediction and analysis.

Research Area(s)

  • Epidermal growth factor receptor, non-small-cell lung carcinoma, tyrosine kinase inhibitor, gefitinib, binding free energy, binding site, alpha shape modeling

Citation Format(s)

An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment. / Ma, Lichun; Wang, Debby D.; Zou, Bin; Yan, Hong.

In: IEEE/ACM Transactions on Computational Biology and Bioinformatics, Vol. 14, No. 5, 01.09.2017, p. 1187-1194.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review