An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II

Linfeng Huang; Alexandra M. E. Jones; Iain Searle; Kanu Patel; Hannes Vogler; Nina C. Hubner; David C. Baulcombe

doi:10.1038/nsmb.1539

An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II

Linfeng Huang, Alexandra M. E. Jones, Iain Searle, Kanu Patel, Hannes Vogler, Nina C. Hubner, David C. Baulcombe

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

116 Citations (Scopus)

Abstract

Genetic evidence indicates that plant-specific homologs of DNA-dependent RNA polymerase (Pol) II large subunits form Pol IV and Pol V complexes involved in small interfering RNA production and RNA-directed DNA methylation. Here we describe evidence that Pol V contains subunits shared with Pol II, but that RNA polymerase II subunit (RPB)-4 is missing from Pol V and that RPB5 is present as a Pol V-specific isomer, RPB5b. Pol V also has other proteins that are not present in Pol II, consistent with a role of this complex as an effector of silencing. © 2009 Nature America, Inc. All rights reserved.

Original language	English
Pages (from-to)	91-93
Journal	Nature Structural and Molecular Biology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1038/nsmb.1539
Publication status	Published - Jan 2009
Externally published	Yes

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abstract = "Genetic evidence indicates that plant-specific homologs of DNA-dependent RNA polymerase (Pol) II large subunits form Pol IV and Pol V complexes involved in small interfering RNA production and RNA-directed DNA methylation. Here we describe evidence that Pol V contains subunits shared with Pol II, but that RNA polymerase II subunit (RPB)-4 is missing from Pol V and that RPB5 is present as a Pol V-specific isomer, RPB5b. Pol V also has other proteins that are not present in Pol II, consistent with a role of this complex as an effector of silencing. {\textcopyright} 2009 Nature America, Inc. All rights reserved.",

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AU - Huang, Linfeng

AU - Jones, Alexandra M. E.

AU - Searle, Iain

AU - Patel, Kanu

AU - Vogler, Hannes

AU - Hubner, Nina C.

AU - Baulcombe, David C.

PY - 2009/1

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N2 - Genetic evidence indicates that plant-specific homologs of DNA-dependent RNA polymerase (Pol) II large subunits form Pol IV and Pol V complexes involved in small interfering RNA production and RNA-directed DNA methylation. Here we describe evidence that Pol V contains subunits shared with Pol II, but that RNA polymerase II subunit (RPB)-4 is missing from Pol V and that RPB5 is present as a Pol V-specific isomer, RPB5b. Pol V also has other proteins that are not present in Pol II, consistent with a role of this complex as an effector of silencing. © 2009 Nature America, Inc. All rights reserved.

AB - Genetic evidence indicates that plant-specific homologs of DNA-dependent RNA polymerase (Pol) II large subunits form Pol IV and Pol V complexes involved in small interfering RNA production and RNA-directed DNA methylation. Here we describe evidence that Pol V contains subunits shared with Pol II, but that RNA polymerase II subunit (RPB)-4 is missing from Pol V and that RPB5 is present as a Pol V-specific isomer, RPB5b. Pol V also has other proteins that are not present in Pol II, consistent with a role of this complex as an effector of silencing. © 2009 Nature America, Inc. All rights reserved.

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DO - 10.1038/nsmb.1539

M3 - RGC 21 - Publication in refereed journal

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VL - 16

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EP - 93

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An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II

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