An analytical method for the determination of perfluorinated compounds in whole blood using acetonitrile and solid phase extraction methods

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Leo W.Y. Yeung
  • Sachi Taniyasu
  • Kurunthachalam Kannan
  • Della Z.Y. Xu
  • Keerthi S. Guruge
  • And 2 others
  • Paul K.S. Lam
  • Nobuyoshi Yamashita

Detail(s)

Original languageEnglish
Pages (from-to)4950-4956
Journal / PublicationJournal of Chromatography A
Volume1216
Issue number25
Publication statusPublished - 19 Jun 2009

Abstract

A method for the analysis of perfluorinated compounds (perfluoroalkyl sulfonates: C4, C6, C8, C10; perfluoroalkyl sulfinates: C6, C8, C10; perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamidoacetate, perfluorocarboxylates: C4-C14; fluorotelomer carboxylate (7:3, 8:2) in whole blood using acetonitrile and OASIS WAX® solid phase extraction (SPE) cartridge was developed. Separation of target compounds in two HPLC columns (ion exchange JJ50-2D and C18 Betasil columns) was examined. Matrix recoveries of the developed methods ranged from 70% to 120%. Separation of possible inferences such as taurodeoxycholic acid (TDC) was accomplished using an ion exchange JJ50-2D column, and this separation was validated using whole blood of different animals. © 2009 Elsevier B.V. All rights reserved.

Research Area(s)

  • Acetonitrile, Formic acid, Perfluorooctanesulfonate, Solid phase extraction, Taurodeoxycholic acid, Whole blood

Citation Format(s)

An analytical method for the determination of perfluorinated compounds in whole blood using acetonitrile and solid phase extraction methods. / Yeung, Leo W.Y.; Taniyasu, Sachi; Kannan, Kurunthachalam; Xu, Della Z.Y.; Guruge, Keerthi S.; Lam, Paul K.S.; Yamashita, Nobuyoshi.

In: Journal of Chromatography A, Vol. 1216, No. 25, 19.06.2009, p. 4950-4956.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review