An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Yong He
  • Junli Yu
  • Xiangzi Hu
  • Shumei Huang
  • Lili Cai
  • Huatang Zhang
  • Yin Jiang
  • Yongguang Jia

Detail(s)

Original languageEnglish
Pages (from-to)13323-13326
Journal / PublicationChemical Communications
Volume56
Issue number87
Online published30 Sep 2020
Publication statusPublished - 11 Nov 2020

Abstract

Herein, a new fluorescent probe, AE-Phos, is reported for detecting the ALP activity with the combined advantages of aggregation-induced emission (AIE) and excited state intramolecular proton transfer (ESIPT). Further detailed fluorescence experiments demonstrated that AE-Phos exhibited excellent selectivity and sensitivity, a large Stokes shift, and a fast response towards ALP. Furthermore, AE-Phos was applied to imaging the ALP activity in different cell lines quantitatively. This journal is

Citation Format(s)

An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines. / He, Yong; Yu, Junli; Hu, Xiangzi; Huang, Shumei; Cai, Lili; Yang, Liu; Zhang, Huatang; Jiang, Yin; Jia, Yongguang; Sun, Hongyan.

In: Chemical Communications, Vol. 56, No. 87, 11.11.2020, p. 13323-13326.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review