An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines

Yong He; Junli Yu; Xiangzi Hu; Shumei Huang; Lili Cai; Liu Yang; Huatang Zhang; Yin Jiang; Yongguang Jia; Hongyan Sun

doi:10.1039/d0cc06129h

Author(s)

Yong He
Junli Yu
Xiangzi Hu
Shumei Huang
Lili Cai
Huatang Zhang
Yin Jiang
Yongguang Jia

Related Research Unit(s)

Detail(s)

Original language	English
Pages (from-to)	13323-13326
Journal / Publication	Chemical Communications
Volume	56
Issue number	87
Online published	30 Sep 2020
Publication status	Published - 11 Nov 2020

Link(s)

DOI	DOI https://doi.org/10.1039/d0cc06129h Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85095461563&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(3d0aee39-51cc-4c54-9f99-02feb6203dfe).html

Abstract

Herein, a new fluorescent probe, AE-Phos, is reported for detecting the ALP activity with the combined advantages of aggregation-induced emission (AIE) and excited state intramolecular proton transfer (ESIPT). Further detailed fluorescence experiments demonstrated that AE-Phos exhibited excellent selectivity and sensitivity, a large Stokes shift, and a fast response towards ALP. Furthermore, AE-Phos was applied to imaging the ALP activity in different cell lines quantitatively. This journal is

Citation Format(s)

[ RIS ] [ BibTeX ]

An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines. / He, Yong; Yu, Junli; Hu, Xiangzi; Huang, Shumei; Cai, Lili; Yang, Liu; Zhang, Huatang; Jiang, Yin; Jia, Yongguang; Sun, Hongyan.

In: Chemical Communications, Vol. 56, No. 87, 11.11.2020, p. 13323-13326.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

He, Y, Yu, J, Hu, X, Huang, S, Cai, L, Yang, L, Zhang, H, Jiang, Y, Jia, Y & Sun, H 2020, 'An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines', Chemical Communications, vol. 56, no. 87, pp. 13323-13326. https://doi.org/10.1039/d0cc06129h

He, Y., Yu, J., Hu, X., Huang, S., Cai, L., Yang, L., Zhang, H., Jiang, Y., Jia, Y., & Sun, H. (2020). An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines. Chemical Communications, 56(87), 13323-13326. https://doi.org/10.1039/d0cc06129h

He Y, Yu J, Hu X, Huang S, Cai L, Yang L et al. An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines. Chemical Communications. 2020 Nov 11;56(87):13323-13326. https://doi.org/10.1039/d0cc06129h

He, Yong ; Yu, Junli ; Hu, Xiangzi ; Huang, Shumei ; Cai, Lili ; Yang, Liu ; Zhang, Huatang ; Jiang, Yin ; Jia, Yongguang ; Sun, Hongyan. / An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines. In: Chemical Communications. 2020 ; Vol. 56, No. 87. pp. 13323-13326.