An acoustic wave sensor incorporated with a microfluidic chip for analyzing muscle cell contraction
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
---|---|
Pages (from-to) | 225-231 |
Journal / Publication | Analyst |
Volume | 128 |
Issue number | 3 |
Publication status | Published - 1 Mar 2003 |
Externally published | Yes |
Link(s)
Abstract
We report the fabrication of a microfluidic chip or lab-on-a-chip integrated with a thickness-shear mode (TSM) acoustic wave sensor for muscle cell analysis. The sensor, essentially an AT-cut quartz crystal, serves as a detector for recording changes in acoustic wave properties occurring in an attached cardiomyocyte (single heart muscle cell) during its contraction and relaxation. Presumably, the changes resulted from alterations in viscoelastic properties (e.g. stiffness) of the cells. The effects of excitation electrode size, the presence of a microfluidic channel plate, and liquid loading on the sensor were first examined. Thereafter, muscle cell contraction analysis upon chemical stimuli were described. The potential of the chip for screening of cardiovascular drugs is discussed.
Bibliographic Note
Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].
Citation Format(s)
An acoustic wave sensor incorporated with a microfluidic chip for analyzing muscle cell contraction. / Li, Paul C. H.; Wang, Weijie; Parameswaran, M.
In: Analyst, Vol. 128, No. 3, 01.03.2003, p. 225-231.
In: Analyst, Vol. 128, No. 3, 01.03.2003, p. 225-231.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review