An acoustic wave sensor incorporated with a microfluidic chip for analyzing muscle cell contraction

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)225-231
Journal / PublicationAnalyst
Volume128
Issue number3
Publication statusPublished - 1 Mar 2003
Externally publishedYes

Abstract

We report the fabrication of a microfluidic chip or lab-on-a-chip integrated with a thickness-shear mode (TSM) acoustic wave sensor for muscle cell analysis. The sensor, essentially an AT-cut quartz crystal, serves as a detector for recording changes in acoustic wave properties occurring in an attached cardiomyocyte (single heart muscle cell) during its contraction and relaxation. Presumably, the changes resulted from alterations in viscoelastic properties (e.g. stiffness) of the cells. The effects of excitation electrode size, the presence of a microfluidic channel plate, and liquid loading on the sensor were first examined. Thereafter, muscle cell contraction analysis upon chemical stimuli were described. The potential of the chip for screening of cardiovascular drugs is discussed.

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Citation Format(s)

An acoustic wave sensor incorporated with a microfluidic chip for analyzing muscle cell contraction. / Li, Paul C. H.; Wang, Weijie; Parameswaran, M.

In: Analyst, Vol. 128, No. 3, 01.03.2003, p. 225-231.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review