An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy

Sun Y. S. Chow; Pui-Chi Lo; Dennis K. P. Ng

doi:10.1039/c6dt02283a

An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy

Sun Y. S. Chow, Pui-Chi Lo^*, Dennis K. P. Ng^*

^*Corresponding author for this work

Department of Biomedical Sciences

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

19 Citations (Scopus)

Abstract

An acetal-linked self-quenched zinc(ii) phthalocyanine tetramer has been prepared. In an acidic environment in phosphate buffered saline or inside tumour cells, the phthalocyanine units of the tetramer are separated thereby restoring the fluorescence emission and singlet oxygen production. This response enables this compound to serve as a promising activatable photosensitiser for photodynamic therapy.

Original language	English
Pages (from-to)	13021-13024
Journal	Dalton Transactions
Volume	45
Issue number	33
Online published	29 Jun 2016
DOIs	https://doi.org/10.1039/c6dt02283a
Publication status	Published - 7 Sept 2016

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title = "An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy",

abstract = "An acetal-linked self-quenched zinc(ii) phthalocyanine tetramer has been prepared. In an acidic environment in phosphate buffered saline or inside tumour cells, the phthalocyanine units of the tetramer are separated thereby restoring the fluorescence emission and singlet oxygen production. This response enables this compound to serve as a promising activatable photosensitiser for photodynamic therapy.",

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AU - Lo, Pui-Chi

AU - Ng, Dennis K. P.

PY - 2016/9/7

Y1 - 2016/9/7

N2 - An acetal-linked self-quenched zinc(ii) phthalocyanine tetramer has been prepared. In an acidic environment in phosphate buffered saline or inside tumour cells, the phthalocyanine units of the tetramer are separated thereby restoring the fluorescence emission and singlet oxygen production. This response enables this compound to serve as a promising activatable photosensitiser for photodynamic therapy.

AB - An acetal-linked self-quenched zinc(ii) phthalocyanine tetramer has been prepared. In an acidic environment in phosphate buffered saline or inside tumour cells, the phthalocyanine units of the tetramer are separated thereby restoring the fluorescence emission and singlet oxygen production. This response enables this compound to serve as a promising activatable photosensitiser for photodynamic therapy.

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DO - 10.1039/c6dt02283a

M3 - RGC 21 - Publication in refereed journal

SN - 1477-9226

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EP - 13024

JO - Dalton Transactions

JF - Dalton Transactions

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ER -

An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy

Abstract

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