Amphiphilic Diketopyrrolopyrrole Derivatives for Efficient Near-Infrared Fluorescence Imaging and Photothermal Therapy

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

8 Scopus Citations
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Author(s)

  • Xiuli Zheng
  • Shuaishuai Bian
  • Weimin Liu
  • Chuangli Zhang
  • Jiasheng Wu
  • Haohui Ren
  • Pengfei Wang

Detail(s)

Original languageEnglish
Pages (from-to)26575-26582
Journal / PublicationACS Omega
Volume6
Issue number40
Online published28 Sept 2021
Publication statusPublished - 12 Oct 2021

Link(s)

Abstract

The design and synthesis of single-molecule amphiphilic and multifunctional phototherapeutic agents are important to cancer diagnosis and therapy. In this work, we developed three amphiphilic diketopyrrolopyrrole derivatives (TPADPP, DTPADPP, and TPADDPP) with different donor-acceptor structures and poly(ethylene glycol) side chains. The corresponding nanoparticles (NPs) were obtained via a self-assembly from three amphiphilic DPP derivatives and used as smart phototherapeutic agents for tumor diagnosis and treatment. The three amphiphilic DPP NPs exhibited near-infrared (NIR) emissions and good biocompatibility. Thus, they could be used as fluorescence (FL) imaging agents for guided therapy. DTPADPP NPs and TPADDPP NPs also displayed excellent photothermal performance and high accumulation in the tumor. Owing to these beneficial features, the DTPADPP NPs and TPADDPP NPs synthesized herein are suitable for NIR FL imaging and effective photothermal therapy against the tumor in vivo.

Research Area(s)

Citation Format(s)

Amphiphilic Diketopyrrolopyrrole Derivatives for Efficient Near-Infrared Fluorescence Imaging and Photothermal Therapy. / Zheng, Xiuli; Bian, Shuaishuai; Liu, Weimin et al.
In: ACS Omega, Vol. 6, No. 40, 12.10.2021, p. 26575-26582.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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