Amberlite IRA 402(OH) Mediated Green Synthesis of Novel Benzothiazole-quinoline Conjugates as Cancer Theranostics

We have introduced Amberlite IRA 402(OH) mediated green synthesis of benzothiazolyl quinoline based fluorescent scaffolds (6a-l) for cancer theranostic application. Compounds 6b (8-[2-(2-benzothiazol-2-yl-phenoxy)-ethoxy]-5,7-dibromoquinoline),6d (8-[2-(2-benzothiazol-2-yl-phenoxy)-ethoxy]-5-chloro-7-iodoquinoline) and6g (8-[2-(2-benzothiazol-2-yl-phenoxy)-propoxy]-5-chloroquinolin -e) demonstrated more or comparable cytotoxicity tocisplatin against all the tested cancer cell lines. Most of the synthesized compounds are 3-25 folds more selective in cancer cell line than normal fibroblast (MRC-5 or HEK-293). It was also evident that compound 6a (8-[2-(2-benzothiazol-2-yl-phenoxy)-ethoxy]-quinoline) can be utilized as cancer theranostic agent since it has good quantum yield in water, significant cellular uptake, high potency and selectivity in all the cancer cell lines.