Amantadine Surface-Modified Silver Nanorods Improves Immunotherapy of HIV Vaccine Against HIV-Infected Cells

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Weiyu Li
  • Yanling Hao
  • Xie Hao
  • Runzhi Li
  • Zhangjie Nan
  • Hongying Zhang
  • Yiming Shao
  • Ye Liu

Detail(s)

Original languageEnglish
Pages (from-to)28494-28501
Journal / PublicationACS Applied Materials and Interfaces
Volume10
Issue number34
Publication statusPublished - 29 Aug 2018
Externally publishedYes

Abstract

Surface modifications can endow nanomaterials with presupposed immunoregulatory functions to optimize vaccine-induced immune responses. In this work, we modified an immunoregulatory molecule, amantadine (Ada), on the outermost layer of PVP-PEG-coated silver nanorods (Ada-PVP-PEG silver nanorods). Such Ada surface-modified silver nanorods promote HIV vaccine-triggered cytotoxic lymphocytes (CTLs) to produce around eightfold stronger tumor necrosis factor alpha (TNF-α) in vivo. The enhancement of HIV-specific CTL-derived TNF-α significantly facilitates the death of HIV-infected cells (from 28.86 to 84.19%) and reduces HIV production (around sixfold). This work supports the critical role of surface modifications of nanomaterials in fundamentally improving the immunotherapy of HIV vaccine against HIV-infected cells. © 2018 American Chemical Society.

Research Area(s)

  • HIV vaccine, HIV-infected cells, immunotherapy, silver nanorods, surface modification

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Amantadine Surface-Modified Silver Nanorods Improves Immunotherapy of HIV Vaccine Against HIV-Infected Cells. / Li, Weiyu; Balachandran, Yekkuni L.; Hao, Yanling et al.
In: ACS Applied Materials and Interfaces, Vol. 10, No. 34, 29.08.2018, p. 28494-28501.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review