Abstract
Surface modifications can endow nanomaterials with presupposed immunoregulatory functions to optimize vaccine-induced immune responses. In this work, we modified an immunoregulatory molecule, amantadine (Ada), on the outermost layer of PVP-PEG-coated silver nanorods (Ada-PVP-PEG silver nanorods). Such Ada surface-modified silver nanorods promote HIV vaccine-triggered cytotoxic lymphocytes (CTLs) to produce around eightfold stronger tumor necrosis factor alpha (TNF-α) in vivo. The enhancement of HIV-specific CTL-derived TNF-α significantly facilitates the death of HIV-infected cells (from 28.86 to 84.19%) and reduces HIV production (around sixfold). This work supports the critical role of surface modifications of nanomaterials in fundamentally improving the immunotherapy of HIV vaccine against HIV-infected cells. © 2018 American Chemical Society.
| Original language | English |
|---|---|
| Pages (from-to) | 28494-28501 |
| Journal | ACS Applied Materials and Interfaces |
| Volume | 10 |
| Issue number | 34 |
| DOIs | |
| Publication status | Published - 29 Aug 2018 |
| Externally published | Yes |
Bibliographical note
Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].Funding
We thank Scientific Research Improvement Project of Beijing University of Agriculture (Project GZL2018001), Beijing Outstanding Talent Training for Young Backbone Individual Projects (Project 2016000020124G049), Research Fund for Young Scientists of BUA (Project SXQN201805), National Science Foundation of China (31500816), and the Ministry of Science and Technology of China (2018ZX10731101-001-011) for the financial support.
Research Keywords
- HIV vaccine
- HIV-infected cells
- immunotherapy
- silver nanorods
- surface modification
