Altered synaptic plasticity of the longitudinal dentate gyrus network in noise-induced anxiety

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jaydeep Roy
  • Chi Him Poon
  • Jinho Lee
  • Dajin Cho
  • Minseok Lee
  • Lee Wei Lim
  • Shaowen Bao
  • Sunggu Yang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number104364
Journal / PublicationiScience
Online published6 May 2022
Publication statusOnline published - 6 May 2022

Abstract

Anxiety is characteristic comorbidity of noise-induced hearing loss (NIHL), which causes physiological changes within the dentate gyrus (DG), a subfield of the hippocampus that modulates anxiety. However, which DG circuit underlies hearing loss-induced anxiety remains unknown. We utilize an NIHL mouse model to investigate short- and long-term synaptic plasticity in DG networks. The recently discovered longitudinal DG-DG network is a collateral of DG neurons synaptically connected with neighboring DG neurons and displays robust synaptic efficacy and plasticity. Furthermore, animals with NIHL demonstrate increased anxiety-like behaviors similar to a response to chronic restraint stress. These behaviors are concurrent with enhanced synaptic responsiveness and suppressed short- and long-term synaptic plasticity in the longitudinal DG-DG network but not in the transverse DG-CA3 connection. These findings suggest that DG-related anxiety is typified by synaptic alteration in the longitudinal DG-DG network.

Research Area(s)

  • hearing loss, sensory deprivation, dorsoventral hippocampus, stress

Citation Format(s)

Altered synaptic plasticity of the longitudinal dentate gyrus network in noise-induced anxiety. / Pak, Sojeong; Choi, Gona; Roy, Jaydeep; Poon, Chi Him; Lee, Jinho; Cho, Dajin; Lee, Minseok; Lim, Lee Wei; Bao, Shaowen; Yang, Sunggu; Yang, Sungchil.

In: iScience, 06.05.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review