Altered D-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Peter C. M. van Zijl
  • Celia M. Dong
  • Gerald W. Y. Cheng
  • Kai-Hei Tse
  • Linda Knutsson
  • Lin Chen
  • Ed X. Wu
  • Jiadi Xu

Detail(s)

Original languageEnglish
Article numbereaba3884
Journal / PublicationScience advances
Volume6
Issue number20
Online published13 May 2020
Publication statusPublished - 13 May 2020

Abstract

Altered cerebral glucose uptake is one of the hallmarks of Alzheimer’s disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor D-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI.

Citation Format(s)

Altered D-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI. / Huang, Jianpan; van Zijl, Peter C. M.; Han, Xiongqi; Dong, Celia M.; Cheng, Gerald W. Y.; Tse, Kai-Hei; Knutsson, Linda; Chen, Lin; Lai, Joseph H. C.; Wu, Ed X.; Xu, Jiadi; Chan, Kannie W. Y.

In: Science advances, Vol. 6, No. 20, eaba3884, 13.05.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal