AL-Net: Adaptive Learning for Enhanced Cell Nucleus Segmentation in Pathological Images

Precise segmentation of cell nuclei in pathological images is the foundation of cancer diagnosis and quantitative analysis, but blurred boundaries, scale variability, and staining differences have long constrained its reliability. To address this, this paper proposes AL-Net—an adaptive learning network that breaks through these bottlenecks through three innovative mechanisms: First, it integrates dilated convolutions with attention-guided skip connections to dynamically integrate multi-scale contextual information, adapting to variations in cell nucleus morphology and size. Second, it employs self-scheduling loss optimization: during the initial training phase, it focuses on region segmentation (Dice loss) and later switches to a boundary refinement stage, introducing gradient manifold constraints to sharpen edge localization. Finally, it designs an adaptive optimizer strategy, leveraging symbolic exploration (Lion) to accelerate convergence, and switches to gradient fine-tuning after reaching a dynamic threshold to stabilize parameters. On the 2018 Data Science Bowl dataset, AL-Net achieved state-of-the-art performance (Dice coefficient 92.96%, IoU 86.86%), reducing boundary error by 15% compared to U-Net/DeepLab; in cross-domain testing (ETIS/ColonDB polyp segmentation), it demonstrated over 80% improvement in generalization performance. AL-Net establishes a new adaptive learning paradigm for computational pathology, significantly enhancing diagnostic reliability. © 2025 by the authors.