Aggregation-Induced Fluorogens in Bio-Detection, Tumor Imaging, and Therapy : A Review

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Original languageEnglish
Pages (from-to)420-436
Journal / PublicationCCS Chemistry
Issue number2
Online published27 Oct 2021
Publication statusPublished - Feb 2022
Externally publishedYes


Aggregation-induced emission (AIE) fluorogens produce strong, stable fluorescence upon aggregation, thus enabling a new frontier in bio-detection, cell imaging, and other biomedical applications. In this review, we summarize the recent developments of AIE fluorogen design strategy, bio-detection, cell imaging, tumor imaging, vascular imaging, and image-guided tumor therapy. We highlight a section on the microfluidic approach to synthesize AIE nanoparticles (NPs) and current challenges and potentials of AIE NPs. © 2022 Chinese Chemical Society. All right reserved.

Research Area(s)

  • Aggregation-induced emission, Bio-detection, Bio-imaging, Image-guided therapy, Microfluidics, NIR AIEgens, Two-photon AIEgens

Citation Format(s)