Aggregation-Induced Emission (AIE), Life and Health

Haoran Wang; Qiyao Li; Parvej Alam; Haotian Bai; Vandana Bhalla; Martin R. Bryce; Mingyue Cao; Chao Chen; Sijie Chen; Xirui Chen; Yuncong Chen; Zhijun Chen; Dongfeng Dang; Dan Ding; Siyang Ding; Yanhong Duo; Meng Gao; Wei He; Xuewen He; Xuechuan Hong; Yuning Hong; Jing-Jing Hu; Rong Hu; Xiaolin Huang; Tony D. James; Xingyu Jiang; Gen-Ichi Konishi; Ryan T K Kwok; Jacky W Y Lam; Chunbin Li; Haidong Li; Kai Li; Nan Li; Wei-Jian Li; Ying Li; Xing-Jie Liang; Yongye Liang; Bin Liu; Guozhen Liu; Xingang Liu; Xiaoding Lou; Xin-Yue Lou; Liang Luo; Paul R. McGonigal; Zong-Wan Mao; Guangle Niu; Tze Cin Owyong; Andrea Pucci; Jun Qian; Anjun Qin; Zijie Qiu; Andrey L. Rogach; Bo Situ; Kazuo Tanaka; Youhong Tang; Bingnan Wang; Dong Wang; Jianguo Wang; Wei Wang; Wen-Xiong Wang; Wen-Jin Wang; Xinyuan Wang; Yi-Feng Wang; Shuizhu Wu; Yifan Wu; Yonghua Xiong; Ruohan Xu; Chenxu Yan; Saisai Yan; Hai-Bo Yang; Lin-Lin Yang; Mingwang Yang; Ying-Wei Yang; Juyoung Yoon; Shuang-Quan Zang; Jiangjiang Zhang; Pengfei Zhang; Tianfu Zhang; Xin Zhang; Xin Zhang; Na Zhao; Zheng Zhao; Jie Zheng; Lei Zheng; Zheng Zheng; Ming-Qiang Zhu; Wei-Hong Zhu; Hang Zou; Ben Zhong Tang

doi:10.1021/acsnano.3c03925

Aggregation-Induced Emission (AIE), Life and Health

Haoran Wang
, Qiyao Li
, Parvej Alam^*
, Haotian Bai^*
, Vandana Bhalla^*
, Martin R. Bryce^*
, Mingyue Cao
, Chao Chen
, Sijie Chen^*
, Xirui Chen
, Yuncong Chen^*
, Zhijun Chen^*
, Dongfeng Dang^*
, Dan Ding^*
, Siyang Ding
, Yanhong Duo^*
, Meng Gao^*
, Wei He
, Xuewen He^*
, Xuechuan Hong^*

Yuning Hong^*, Jing-Jing Hu, Rong Hu^*, Xiaolin Huang^*, Tony D. James^*, Xingyu Jiang^*, Gen-Ichi Konishi^*, Ryan T K Kwok^*, Jacky W Y Lam^*, Chunbin Li, Haidong Li, Kai Li^*, Nan Li, Wei-Jian Li, Ying Li^*, Xing-Jie Liang^*, Yongye Liang^*, Bin Liu^*, Guozhen Liu^*, Xingang Liu, Xiaoding Lou^*, Xin-Yue Lou, Liang Luo^*, Paul R. McGonigal^*, Zong-Wan Mao^*, Guangle Niu^*, Tze Cin Owyong, Andrea Pucci^*, Jun Qian^*, Anjun Qin^*, Zijie Qiu^*, Andrey L. Rogach^*, Bo Situ, Kazuo Tanaka^*, Youhong Tang^*, Bingnan Wang, Dong Wang^*, Jianguo Wang^*, Wei Wang, Wen-Xiong Wang^*, Wen-Jin Wang, Xinyuan Wang, Yi-Feng Wang, Shuizhu Wu^*, Yifan Wu, Yonghua Xiong, Ruohan Xu, Chenxu Yan, Saisai Yan, Hai-Bo Yang^*, Lin-Lin Yang, Mingwang Yang, Ying-Wei Yang^*, Juyoung Yoon^*, Shuang-Quan Zang^*, Jiangjiang Zhang, Pengfei Zhang^*, Tianfu Zhang, Xin Zhang^*, Xin Zhang, Na Zhao^*, Zheng Zhao^*, Jie Zheng^*, Lei Zheng^*, Zheng Zheng^*, Ming-Qiang Zhu^*, Wei-Hong Zhu^*, Hang Zou, Ben Zhong Tang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

314 Citations (Scopus)

193 Downloads (CityUHK Scholars)

Abstract

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health.

© 2023 The Authors. Published by American Chemical Society

Original language	English
Pages (from-to)	14347-14405
Journal	ACS Nano
Volume	17
Issue number	15
Online published	24 Jul 2023
DOIs	https://doi.org/10.1021/acsnano.3c03925
Publication status	Published - 8 Aug 2023

Research Keywords

aggregation-induced emission
bioimaging
biomedical application
combined therapy
detection
luminescent material
monitoring
phototheranostics
precision medicine

Publisher's Copyright Statement

This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

RGC Funding Information

RGC-funded

Access Output

10.1021/acsnano.3c03925

163523386.pdfFinal Published version, 10.7 MBLicence: CC BY

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Cite this

@article{e44063c76a974c29afd78ab30230fdae,

title = "Aggregation-Induced Emission (AIE), Life and Health",

abstract = "Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health. {\textcopyright} 2023 The Authors. Published by American Chemical Society",

keywords = "aggregation-induced emission, bioimaging, biomedical application, combined therapy, detection, luminescent material, monitoring, phototheranostics, precision medicine",

author = "Haoran Wang and Qiyao Li and Parvej Alam and Haotian Bai and Vandana Bhalla and Bryce, \{Martin R.\} and Mingyue Cao and Chao Chen and Sijie Chen and Xirui Chen and Yuncong Chen and Zhijun Chen and Dongfeng Dang and Dan Ding and Siyang Ding and Yanhong Duo and Meng Gao and Wei He and Xuewen He and Xuechuan Hong and Yuning Hong and Jing-Jing Hu and Rong Hu and Xiaolin Huang and James, \{Tony D.\} and Xingyu Jiang and Gen-Ichi Konishi and Kwok, \{Ryan T K\} and Lam, \{Jacky W Y\} and Chunbin Li and Haidong Li and Kai Li and Nan Li and Wei-Jian Li and Ying Li and Xing-Jie Liang and Yongye Liang and Bin Liu and Guozhen Liu and Xingang Liu and Xiaoding Lou and Xin-Yue Lou and Liang Luo and McGonigal, \{Paul R.\} and Zong-Wan Mao and Guangle Niu and Owyong, \{Tze Cin\} and Andrea Pucci and Jun Qian and Anjun Qin and Zijie Qiu and Rogach, \{Andrey L.\} and Bo Situ and Kazuo Tanaka and Youhong Tang and Bingnan Wang and Dong Wang and Jianguo Wang and Wei Wang and Wen-Xiong Wang and Wen-Jin Wang and Xinyuan Wang and Yi-Feng Wang and Shuizhu Wu and Yifan Wu and Yonghua Xiong and Ruohan Xu and Chenxu Yan and Saisai Yan and Hai-Bo Yang and Lin-Lin Yang and Mingwang Yang and Ying-Wei Yang and Juyoung Yoon and Shuang-Quan Zang and Jiangjiang Zhang and Pengfei Zhang and Tianfu Zhang and Xin Zhang and Xin Zhang and Na Zhao and Zheng Zhao and Jie Zheng and Lei Zheng and Zheng Zheng and Ming-Qiang Zhu and Wei-Hong Zhu and Hang Zou and Tang, \{Ben Zhong\}",

year = "2023",

month = aug,

day = "8",

doi = "10.1021/acsnano.3c03925",

language = "English",

volume = "17",

pages = "14347--14405",

journal = "ACS Nano",

issn = "1936-086X",

publisher = "American Chemical Society",

number = "15",

}

Wang, H, Li, Q, Alam, P, Bai, H, Bhalla, V, Bryce, MR, Cao, M, Chen, C, Chen, S, Chen, X, Chen, Y, Chen, Z, Dang, D, Ding, D, Ding, S, Duo, Y, Gao, M, He, W, He, X, Hong, X, Hong, Y, Hu, J-J, Hu, R, Huang, X, James, TD, Jiang, X, Konishi, G-I, Kwok, RTK, Lam, JWY, Li, C, Li, H, Li, K, Li, N, Li, W-J, Li, Y, Liang, X-J, Liang, Y, Liu, B, Liu, G, Liu, X, Lou, X, Lou, X-Y, Luo, L, McGonigal, PR, Mao, Z-W, Niu, G, Owyong, TC, Pucci, A, Qian, J, Qin, A, Qiu, Z, Rogach, AL, Situ, B, Tanaka, K, Tang, Y, Wang, B, Wang, D, Wang, J, Wang, W, Wang, W-X, Wang, W-J, Wang, X, Wang, Y-F, Wu, S, Wu, Y, Xiong, Y, Xu, R, Yan, C, Yan, S, Yang, H-B, Yang, L-L, Yang, M, Yang, Y-W, Yoon, J, Zang, S-Q, Zhang, J, Zhang, P, Zhang, T, Zhang, X, Zhang, X, Zhao, N, Zhao, Z, Zheng, J, Zheng, L, Zheng, Z, Zhu, M-Q, Zhu, W-H, Zou, H & Tang, BZ 2023, 'Aggregation-Induced Emission (AIE), Life and Health', ACS Nano, vol. 17, no. 15, pp. 14347-14405. https://doi.org/10.1021/acsnano.3c03925

TY - JOUR

T1 - Aggregation-Induced Emission (AIE), Life and Health

AU - Wang, Haoran

AU - Li, Qiyao

AU - Alam, Parvej

AU - Bai, Haotian

AU - Bhalla, Vandana

AU - Bryce, Martin R.

AU - Cao, Mingyue

AU - Chen, Chao

AU - Chen, Sijie

AU - Chen, Xirui

AU - Chen, Yuncong

AU - Chen, Zhijun

AU - Dang, Dongfeng

AU - Ding, Dan

AU - Ding, Siyang

AU - Duo, Yanhong

AU - Gao, Meng

AU - He, Wei

AU - He, Xuewen

AU - Hong, Xuechuan

AU - Hong, Yuning

AU - Hu, Jing-Jing

AU - Hu, Rong

AU - Huang, Xiaolin

AU - James, Tony D.

AU - Jiang, Xingyu

AU - Konishi, Gen-Ichi

AU - Kwok, Ryan T K

AU - Lam, Jacky W Y

AU - Li, Chunbin

AU - Li, Haidong

AU - Li, Kai

AU - Li, Nan

AU - Li, Wei-Jian

AU - Li, Ying

AU - Liang, Xing-Jie

AU - Liang, Yongye

AU - Liu, Bin

AU - Liu, Guozhen

AU - Liu, Xingang

AU - Lou, Xiaoding

AU - Lou, Xin-Yue

AU - Luo, Liang

AU - McGonigal, Paul R.

AU - Mao, Zong-Wan

AU - Niu, Guangle

AU - Owyong, Tze Cin

AU - Pucci, Andrea

AU - Qian, Jun

AU - Qin, Anjun

AU - Qiu, Zijie

AU - Rogach, Andrey L.

AU - Situ, Bo

AU - Tanaka, Kazuo

AU - Tang, Youhong

AU - Wang, Bingnan

AU - Wang, Dong

AU - Wang, Jianguo

AU - Wang, Wei

AU - Wang, Wen-Xiong

AU - Wang, Wen-Jin

AU - Wang, Xinyuan

AU - Wang, Yi-Feng

AU - Wu, Shuizhu

AU - Wu, Yifan

AU - Xiong, Yonghua

AU - Xu, Ruohan

AU - Yan, Chenxu

AU - Yan, Saisai

AU - Yang, Hai-Bo

AU - Yang, Lin-Lin

AU - Yang, Mingwang

AU - Yang, Ying-Wei

AU - Yoon, Juyoung

AU - Zang, Shuang-Quan

AU - Zhang, Jiangjiang

AU - Zhang, Pengfei

AU - Zhang, Tianfu

AU - Zhang, Xin

AU - Zhao, Na

AU - Zhao, Zheng

AU - Zheng, Jie

AU - Zheng, Lei

AU - Zheng, Zheng

AU - Zhu, Ming-Qiang

AU - Zhu, Wei-Hong

AU - Zou, Hang

AU - Tang, Ben Zhong

PY - 2023/8/8

Y1 - 2023/8/8

N2 - Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health. © 2023 The Authors. Published by American Chemical Society

AB - Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health. © 2023 The Authors. Published by American Chemical Society

KW - aggregation-induced emission

KW - bioimaging

KW - biomedical application

KW - combined therapy

KW - detection

KW - luminescent material

KW - monitoring

KW - phototheranostics

KW - precision medicine

UR - https://www.scopus.com/pages/publications/85167475154

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85167475154&origin=recordpage

U2 - 10.1021/acsnano.3c03925

DO - 10.1021/acsnano.3c03925

M3 - RGC 21 - Publication in refereed journal

C2 - 37486125

SN - 1936-086X

VL - 17

SP - 14347

EP - 14405

JO - ACS Nano

JF - ACS Nano

IS - 15

ER -

Aggregation-Induced Emission (AIE), Life and Health

Abstract

Research Keywords

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CRF-ExtU-Lead: New Aggregation-Induced Emission Systems: Solving the Existing Problems in Bioimaging and Developing New Biological Applications

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Aggregation-Induced Emission (AIE), Life and Health

Abstract

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

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CRF-ExtU-Lead: New Aggregation-Induced Emission Systems: Solving the Existing Problems in Bioimaging and Developing New Biological Applications

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