AGE-RELATED VARIATION IN FRONTAL WHITE-MATTER INTEGRITY MEDIATES VISUOSPATIAL FUNCTION IN NORMAL AGING

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)31A_Invited conference paper (refereed items)

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Author(s)

Detail(s)

Original languageEnglish
Publication statusPublished - Oct 2018

Conference

Title58th Annual Meeting of the Society for Psychophysiological Research (SPR 2018)
LocationQuebec City Convention Centre
PlaceCanada
CityQuebec City
Period3 - 7 October 2018

Abstract

Alterations in brain structure are viewed as neurobiological indicators which are closely tied to cognitive changes in healthy human aging. The current study used diffusion tensor imaging (DTI) tractography to investigate the relationship between age, brain variation in white matter (WM) integrity, and cognitive function. Sixteen younger adults (aged 20-28 years) and 18 healthy older adults (aged 60-75 years) underwent DTI scanning and a standardized battery of neuropsychological measures. Behaviorally, older adults exhibited poorer performance on multiple cognitive measures compared to younger adults. At the neural level, the effects of aging on the WM integrity were evident within interhemispheric (the anterior portion of corpus callosum) and transverse (the right uncinate fasciculus) fibers of the frontal regions, and the cingulum-angular fibers. Our correlation results showed that age-related WM differentially influenced cognitive function, with increased fractional anisotropy values in both anterior corpus callosum and the right cingulum/angular fibers positively correlated with performance on the visuospatial task in older adults. Moreover, mediation analysisfurther revealed that the WM tract integrity of the frontal interhemspheric fibers was a significant mediator of age–visuospatial performance relation in older adults, but not in younger adults. These findings support the vulnerabilityof the frontal WM fibers to normal aging.

Research Area(s)

  • Aging, Individual Differences, Diffusion Tensor Imaging

Bibliographic Note

Information for this record is supplemented by the author(s) concerned.

Citation Format(s)

AGE-RELATED VARIATION IN FRONTAL WHITE-MATTER INTEGRITY MEDIATES VISUOSPATIAL FUNCTION IN NORMAL AGING. / Huang, Chih-Mao ; Fan, Yang-Teng; Fang, Ya-Wen; Tzeng, Ovid; Huang, Hsu-Wen.

2018. 58th Annual Meeting of the Society for Psychophysiological Research (SPR 2018), Quebec City, Canada.

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)31A_Invited conference paper (refereed items)