Age-related and individual differences in brain complexity of resting-state fMRI signals in healthy elderly

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)31A_Invited conference paper (refereed items)

View graph of relations

Author(s)

  • 吳順吉
  • Guan-Yen Chen
  • Pei-Shan Ho
  • Ya-Wen Fang
  • Ovid J.L. Tzeng
  • Chih-Mao Huang

Detail(s)

Original languageEnglish
Pages59
Publication statusPublished - Jan 2019

Conference

Title2019 Taiwan Society of Cognitive Neuroscience Annual meeting
LocationTaiwan
PlaceTaiwan
CityHsinchu
Period26 January 2019

Abstract

Entropy-based complexity of neural signal characterizes intrinsic function of the human brain.

In this resting-state functional magnetic resonance imaging (rs-fMRI) study, we employed multiscale entropy (MSE) analysis to examine age-related and individual differences in the complexity of intrinsic network, brain function and cognition. Specifically, the MSE of blood oxygen level-dependent (BOLD) signals of rs-fMRI data from 90 prior-selected regions-of-interest (ROIs) were estimated in 28 young and 65 healthy older adults. The results showed that healthy older adults exhibited significant reduction in MSE of BOLD signals in fronto-parietal network but increase in MSE of BOLD signals in thalamus, indicating a higher degree of complexity in the aging brain with reduced information transfer between cortical and subcortical regions. Moreover, the MSE of BOLD signals in high-functioning older adults appear to be similar with the MSE of BOLD signals in the default mode and salience networks found in young adults, suggesting a preserved intrinsic network for individuals who age better than others. Our findings provide supportive evidence that complexity of brain activity is declined across the lifespan and associated with the individual variations in neurocognitive performance in the healthy older adults.

Bibliographic Note

Information and the research output category for this record is supplemented by the author(s) concerned.

Citation Format(s)

Age-related and individual differences in brain complexity of resting-state fMRI signals in healthy elderly. / 吳順吉; Chen, Guan-Yen; Ho, Pei-Shan; Fang, Ya-Wen; Tzeng, Ovid J.L.; Huang, Hsu Wen; Huang, Chih-Mao.

2019. 59 2019 Taiwan Society of Cognitive Neuroscience Annual meeting, Hsinchu, Taiwan.

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)31A_Invited conference paper (refereed items)