Age-Related Subcortical Brain Morphology Changes Following Three Hours of Sleep Deprivation

Jie Li

doi:10.3233/SHTI230823

Age-Related Subcortical Brain Morphology Changes Following Three Hours of Sleep Deprivation

Jie Li

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

1 Citation (Scopus)

Abstract

Sleep deprivation (SD) disrupted subcortical regions involved in emotion and attention. However, the age-related changes on subcortical brain morphology in processing of emotion and attention following SD remains unclear. Eighty participants consisting of 43 young people and 37 old people were included in this study. The volumetric analysis and vertex-wise shape analysis were employed to assess age-dependent structural abnormalities after SD. By volumetric analysis, we found significant main effect of deprivation with local atrophy in right amygdala. Shape analysis also showed the significant main effect of age in all subcortical structures. Moreover, the significant correlations between volume changes of bilateral amygdala and left thalamus after SD and scales scores refer to emotion processing and attention were observed in old adults. These findings indicated that SD altered gray matter volume and surface morphology of subcortical regions in old adults and suggested disrupted subcortical regions were associated with emotion and attention in old adults.

Original language	English
Title of host publication	Advances in Biomedical and Bioinformatics Engineering
Subtitle of host publication	Proceedings of the 3rd International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2023)
Editors	Yitao Yu, Binh P. Nguyen, Jun Sang
Publisher	IOS Press
Pages	48-54
Volume	308
ISBN (Electronic)	978-1-64368-433-8
ISBN (Print)	978-1-64368-432-1
DOIs	https://doi.org/10.3233/SHTI230823
Publication status	Published - Jun 2023
Externally published	Yes
Event	2023 3^rd International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2023) - Nanjing, China Duration: 16 Jun 2023 → 18 Jun 2023 http://2023.ic-bbe.org/

Publication series

Name	Studies in Health Technology and Informatics
ISSN (Print)	0926-9630

Conference

Conference	2023 3^rd International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2023)
Place	China
City	Nanjing
Period	16/06/23 → 18/06/23
Internet address	http://2023.ic-bbe.org/

Research Keywords

aging
sleep deprivation
subcortical shape

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10.3233/SHTI230823

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Li, J. (2023). Age-Related Subcortical Brain Morphology Changes Following Three Hours of Sleep Deprivation. In Y. Yu, B. P. Nguyen, & J. Sang (Eds.), Advances in Biomedical and Bioinformatics Engineering: Proceedings of the 3rd International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2023) (Vol. 308, pp. 48-54). (Studies in Health Technology and Informatics). IOS Press. https://doi.org/10.3233/SHTI230823

Li, Jie. / Age-Related Subcortical Brain Morphology Changes Following Three Hours of Sleep Deprivation. Advances in Biomedical and Bioinformatics Engineering: Proceedings of the 3rd International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2023). editor / Yitao Yu ; Binh P. Nguyen ; Jun Sang. Vol. 308 IOS Press, 2023. pp. 48-54 (Studies in Health Technology and Informatics).

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title = "Age-Related Subcortical Brain Morphology Changes Following Three Hours of Sleep Deprivation",

abstract = "Sleep deprivation (SD) disrupted subcortical regions involved in emotion and attention. However, the age-related changes on subcortical brain morphology in processing of emotion and attention following SD remains unclear. Eighty participants consisting of 43 young people and 37 old people were included in this study. The volumetric analysis and vertex-wise shape analysis were employed to assess age-dependent structural abnormalities after SD. By volumetric analysis, we found significant main effect of deprivation with local atrophy in right amygdala. Shape analysis also showed the significant main effect of age in all subcortical structures. Moreover, the significant correlations between volume changes of bilateral amygdala and left thalamus after SD and scales scores refer to emotion processing and attention were observed in old adults. These findings indicated that SD altered gray matter volume and surface morphology of subcortical regions in old adults and suggested disrupted subcortical regions were associated with emotion and attention in old adults.",

keywords = "aging, sleep deprivation, subcortical shape",

author = "Jie Li",

year = "2023",

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doi = "10.3233/SHTI230823",

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series = "Studies in Health Technology and Informatics",

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pages = "48--54",

editor = "Yitao Yu and Nguyen, {Binh P. } and Jun Sang",

booktitle = "Advances in Biomedical and Bioinformatics Engineering",

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note = "2023 3<sup>rd</sup> International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2023) ; Conference date: 16-06-2023 Through 18-06-2023",

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Li, J 2023, Age-Related Subcortical Brain Morphology Changes Following Three Hours of Sleep Deprivation. in Y Yu, BP Nguyen & J Sang (eds), Advances in Biomedical and Bioinformatics Engineering: Proceedings of the 3rd International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2023). vol. 308, Studies in Health Technology and Informatics, IOS Press, pp. 48-54, 2023 3^rd International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2023), Nanjing, China, 16/06/23. https://doi.org/10.3233/SHTI230823

Age-Related Subcortical Brain Morphology Changes Following Three Hours of Sleep Deprivation. / Li, Jie.
Advances in Biomedical and Bioinformatics Engineering: Proceedings of the 3rd International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2023). ed. / Yitao Yu; Binh P. Nguyen; Jun Sang. Vol. 308 IOS Press, 2023. p. 48-54 (Studies in Health Technology and Informatics).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - Age-Related Subcortical Brain Morphology Changes Following Three Hours of Sleep Deprivation

AU - Li, Jie

PY - 2023/6

Y1 - 2023/6

N2 - Sleep deprivation (SD) disrupted subcortical regions involved in emotion and attention. However, the age-related changes on subcortical brain morphology in processing of emotion and attention following SD remains unclear. Eighty participants consisting of 43 young people and 37 old people were included in this study. The volumetric analysis and vertex-wise shape analysis were employed to assess age-dependent structural abnormalities after SD. By volumetric analysis, we found significant main effect of deprivation with local atrophy in right amygdala. Shape analysis also showed the significant main effect of age in all subcortical structures. Moreover, the significant correlations between volume changes of bilateral amygdala and left thalamus after SD and scales scores refer to emotion processing and attention were observed in old adults. These findings indicated that SD altered gray matter volume and surface morphology of subcortical regions in old adults and suggested disrupted subcortical regions were associated with emotion and attention in old adults.

AB - Sleep deprivation (SD) disrupted subcortical regions involved in emotion and attention. However, the age-related changes on subcortical brain morphology in processing of emotion and attention following SD remains unclear. Eighty participants consisting of 43 young people and 37 old people were included in this study. The volumetric analysis and vertex-wise shape analysis were employed to assess age-dependent structural abnormalities after SD. By volumetric analysis, we found significant main effect of deprivation with local atrophy in right amygdala. Shape analysis also showed the significant main effect of age in all subcortical structures. Moreover, the significant correlations between volume changes of bilateral amygdala and left thalamus after SD and scales scores refer to emotion processing and attention were observed in old adults. These findings indicated that SD altered gray matter volume and surface morphology of subcortical regions in old adults and suggested disrupted subcortical regions were associated with emotion and attention in old adults.

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DO - 10.3233/SHTI230823

M3 - RGC 32 - Refereed conference paper (with host publication)

C2 - 38007724

SN - 978-1-64368-432-1

VL - 308

T3 - Studies in Health Technology and Informatics

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EP - 54

BT - Advances in Biomedical and Bioinformatics Engineering

A2 - Yu, Yitao

A2 - Nguyen, Binh P.

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T2 - 2023 3<sup>rd</sup> International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2023)

Y2 - 16 June 2023 through 18 June 2023

ER -

Li J. Age-Related Subcortical Brain Morphology Changes Following Three Hours of Sleep Deprivation. In Yu Y, Nguyen BP, Sang J, editors, Advances in Biomedical and Bioinformatics Engineering: Proceedings of the 3rd International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2023). Vol. 308. IOS Press. 2023. p. 48-54. (Studies in Health Technology and Informatics). doi: 10.3233/SHTI230823

Age-Related Subcortical Brain Morphology Changes Following Three Hours of Sleep Deprivation

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