Affinity Partitioning-Induced Self-Assembly in Aqueous Two-Phase Systems: Templating for Polyelectrolyte Microcapsules

Qingming Ma; Yang Song; Jin Woong Kim; Hong Sung Choi; Ho Cheung Shum

doi:10.1021/acsmacrolett.6b00228

Affinity Partitioning-Induced Self-Assembly in Aqueous Two-Phase Systems: Templating for Polyelectrolyte Microcapsules

Qingming Ma
, Yang Song
, Jin Woong Kim
, Hong Sung Choi
, Ho Cheung Shum^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

79 Citations (Scopus)

Abstract

Affinity partitioning refers to the preferential dissolution of solute molecules in a particular liquid phase of an immiscible liquid-liquid mixture, such as an aqueous two-phase system (ATPS). Affinity partitioning in ATPS is widely used to achieve extraction and purification of biomolecules. However, the potential of applying it to direct the self-assembly of solutes into controlled structures has been largely overlooked. Here we introduce the affinity partitioning of polyelectrolytes in ATPS to induce their self-assembly into polyelectrolyte microcapsules. The approach is purely based on the preferential solubility of different polyelectrolytes in different aqueous phases; therefore it has wide applicability and exhibits excellent compatibility with bioactives. The release of encapsulated components can be triggered by changing the pH value or ionic strength of the surrounding environment. The proposed method represents an important advance in fabricating multifunctional materials and inspires new ways to engineer sophisticated structures with hydrophilic macromolecules. © 2016 American Chemical Society.

Original language	English
Pages (from-to)	666-670
Journal	ACS Macro Letters
Volume	5
Issue number	6
DOIs	https://doi.org/10.1021/acsmacrolett.6b00228
Publication status	Published - 21 Jun 2016
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This research was supported by a collaborative project with Hanyang University, the Early Career Scheme (HKU 707712P) and the General Research Fund (HKU 719813E and 17304514) from the Research Grants Council of Hong Kong, the General Program (21476189/B060201), Young Scholar’s Program (NSFC51206138/E0605), and the Major Research plan (No. 91434202) from the National Natural Science Foundation of China, as well as the Seed Funding Programme for Basic Research (201211159090, 201311159105) and for Applied Research (201309160035) from the University of Hong Kong.

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title = "Affinity Partitioning-Induced Self-Assembly in Aqueous Two-Phase Systems: Templating for Polyelectrolyte Microcapsules",

abstract = "Affinity partitioning refers to the preferential dissolution of solute molecules in a particular liquid phase of an immiscible liquid-liquid mixture, such as an aqueous two-phase system (ATPS). Affinity partitioning in ATPS is widely used to achieve extraction and purification of biomolecules. However, the potential of applying it to direct the self-assembly of solutes into controlled structures has been largely overlooked. Here we introduce the affinity partitioning of polyelectrolytes in ATPS to induce their self-assembly into polyelectrolyte microcapsules. The approach is purely based on the preferential solubility of different polyelectrolytes in different aqueous phases; therefore it has wide applicability and exhibits excellent compatibility with bioactives. The release of encapsulated components can be triggered by changing the pH value or ionic strength of the surrounding environment. The proposed method represents an important advance in fabricating multifunctional materials and inspires new ways to engineer sophisticated structures with hydrophilic macromolecules. {\textcopyright} 2016 American Chemical Society.",

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AU - Song, Yang

AU - Kim, Jin Woong

AU - Choi, Hong Sung

AU - Shum, Ho Cheung

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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N2 - Affinity partitioning refers to the preferential dissolution of solute molecules in a particular liquid phase of an immiscible liquid-liquid mixture, such as an aqueous two-phase system (ATPS). Affinity partitioning in ATPS is widely used to achieve extraction and purification of biomolecules. However, the potential of applying it to direct the self-assembly of solutes into controlled structures has been largely overlooked. Here we introduce the affinity partitioning of polyelectrolytes in ATPS to induce their self-assembly into polyelectrolyte microcapsules. The approach is purely based on the preferential solubility of different polyelectrolytes in different aqueous phases; therefore it has wide applicability and exhibits excellent compatibility with bioactives. The release of encapsulated components can be triggered by changing the pH value or ionic strength of the surrounding environment. The proposed method represents an important advance in fabricating multifunctional materials and inspires new ways to engineer sophisticated structures with hydrophilic macromolecules. © 2016 American Chemical Society.

AB - Affinity partitioning refers to the preferential dissolution of solute molecules in a particular liquid phase of an immiscible liquid-liquid mixture, such as an aqueous two-phase system (ATPS). Affinity partitioning in ATPS is widely used to achieve extraction and purification of biomolecules. However, the potential of applying it to direct the self-assembly of solutes into controlled structures has been largely overlooked. Here we introduce the affinity partitioning of polyelectrolytes in ATPS to induce their self-assembly into polyelectrolyte microcapsules. The approach is purely based on the preferential solubility of different polyelectrolytes in different aqueous phases; therefore it has wide applicability and exhibits excellent compatibility with bioactives. The release of encapsulated components can be triggered by changing the pH value or ionic strength of the surrounding environment. The proposed method represents an important advance in fabricating multifunctional materials and inspires new ways to engineer sophisticated structures with hydrophilic macromolecules. © 2016 American Chemical Society.

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U2 - 10.1021/acsmacrolett.6b00228

DO - 10.1021/acsmacrolett.6b00228

M3 - RGC 21 - Publication in refereed journal

SN - 2161-1653

VL - 5

SP - 666

EP - 670

JO - ACS Macro Letters

JF - ACS Macro Letters

IS - 6

ER -

Affinity Partitioning-Induced Self-Assembly in Aqueous Two-Phase Systems: Templating for Polyelectrolyte Microcapsules

Abstract

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