Adverse health effects and stresses on offspring due to paternal exposure to harmful substances

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

1 Scopus Citations
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Author(s)

  • Jiaqi Sun
  • Miaomiao Teng
  • Fengchang Wu
  • Xiaoli Zhao
  • Yunxia Li
  • Lihui Zhao
  • Wentian Zhao
  • Keng Po Lai
  • John P. Giesy

Detail(s)

Original languageEnglish
Pages (from-to)1059-1084
Journal / PublicationCritical Reviews in Environmental Science and Technology
Volume53
Issue number10
Online published20 Oct 2022
Publication statusPublished - 2023

Abstract

Recent epidemiological investigations report that environmental factors, such as exposure to harmful substances and stress related to unhealthy lifestyles, can result in health risks to organisms. The involvement of paternal exposure to chemicals and stresses, which leads to a negative impact on physiological responses and developmental processes in descendants, has drawn scientific attention. In this comprehensive review, we systematically describe different exposure sources of intergenerational and transgenerational health effects, including smoking, atmospheric fine particulate matter, alcohol, obesogenic diet and chemical toxicants, as well as stress related to unhealthy lifestyles, such as early stress and trauma during early development. Furthermore, effects on paternal lineages through epigenetic mechanisms mediated by germ cells, including effects on reproduction, oxidative stress, nervous and immune systems, were reviewed. Collectively, these effects can affect genetic materials through DNA methylation, small noncoding RNAs and histone modifications in later generations. Specifically, neurotoxicity or brain development caused by paternal inheritance was reviewed for this research. To better understand the epigenetic mechanisms of phenotypic changes and pathological lesions, further studies should emphasize research on the effects on third or fourth generation (i.e., F3 or F4) of offspring, rather than only the first or second generation (i.e., F1 or F2), which is generally done. In particular, how the toxic effects of new pollutants on paternal heritage are transmitted to successive generations (i.e., F3 and onward) should be more fully explored, and attempts should be made to find ways to alleviate the effects of the exposures on offspring. © 2022 Taylor & Francis Group, LLC.

Research Area(s)

  • Epigenetic mechanisms, harmful substances, offspring, paternal exposure, stress responses, toxic effects

Citation Format(s)

Adverse health effects and stresses on offspring due to paternal exposure to harmful substances. / Sun, Jiaqi; Teng, Miaomiao; Wu, Fengchang et al.
In: Critical Reviews in Environmental Science and Technology, Vol. 53, No. 10, 2023, p. 1059-1084.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review