TY - JOUR
T1 - Advancing disease theranostics with ultrasound
T2 - Sono-physics, sono -chemistry, and sono-biology
AU - Zhang, Jianing
AU - Li, Xin
AU - Ma, Yuru
AU - Yu, Xiaomiao
AU - Yuan, Liutianyun
AU - Jia, Shang
AU - Teng, Yue
AU - Liu, Xiuyun
AU - Shi, Zhiyuan
PY - 2026/1/15
Y1 - 2026/1/15
N2 - Ultrasound serves as a bridge between physics, chemistry, and biology, redefining precision medicine by enabling the decoding and manipulation of acoustic-bio interactions. It offers safer, scalable, and patient-centric solutions for a wide range of diseases, from cancer to neurodegenerative disorders. This review explores ultrasound (US)’s transformative potential in modern healthcare through three key frameworks: (1) sono-physics—strategies to enhance cavitation and sonothermal effects, along with their applications in imaging and disease therapy; (2) sono-chemistry—recent advancements in nanomaterial-assisted sonodynamic and sonopiezoelectric therapies, as well as sonopharmacology systems for spatiotemporally controlled drug release and activation; and (3) sono-biology—US's influence on mechanosensitive ion channels, proteins, and gene expression, including their classification, underlying mechanisms, and neuromodulatory applications. Furthermore, we discuss the emerging applications of US in imaging, wearable devices, non-invasive treatments, and medical sensors. Challenges and limitations are critically examined, and constructive insights are provided to advance the future development of US-based theranostics. © 2025 The Author(s)
AB - Ultrasound serves as a bridge between physics, chemistry, and biology, redefining precision medicine by enabling the decoding and manipulation of acoustic-bio interactions. It offers safer, scalable, and patient-centric solutions for a wide range of diseases, from cancer to neurodegenerative disorders. This review explores ultrasound (US)’s transformative potential in modern healthcare through three key frameworks: (1) sono-physics—strategies to enhance cavitation and sonothermal effects, along with their applications in imaging and disease therapy; (2) sono-chemistry—recent advancements in nanomaterial-assisted sonodynamic and sonopiezoelectric therapies, as well as sonopharmacology systems for spatiotemporally controlled drug release and activation; and (3) sono-biology—US's influence on mechanosensitive ion channels, proteins, and gene expression, including their classification, underlying mechanisms, and neuromodulatory applications. Furthermore, we discuss the emerging applications of US in imaging, wearable devices, non-invasive treatments, and medical sensors. Challenges and limitations are critically examined, and constructive insights are provided to advance the future development of US-based theranostics. © 2025 The Author(s)
KW - sono-biology
KW - sono-chemistry
KW - sono-physics
KW - theranostics
KW - ultrasound
UR - http://www.scopus.com/inward/record.url?scp=105027676965&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-105027676965&origin=recordpage
U2 - 10.1016/j.celbio.2025.100313
DO - 10.1016/j.celbio.2025.100313
M3 - RGC 21 - Publication in refereed journal
SN - 3050-5623
JO - Cell Biomaterials
JF - Cell Biomaterials
M1 - 100313
ER -
SDG 3 Good Health and Well-being