Advances in Microfluidic Paper-Based Analytical Devices (µPADs): Design, Fabrication, and Applications

Jian Lin Chen*, Demian Ifeanyi Njoku, Cui Tang, Yaru Gao, Jiayu Chen, Yung-Kang Peng, Hongyan Sun, Guozhu Mao, Min Pan, Nora Fung-Yee Tam*

*Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

19 Citations (Scopus)

Abstract

Microfluidic Paper-based Analytical Devices (µPADs) have emerged as a new class of microfluidic systems, offering numerous advantages over traditional microfluidic chips. These advantages include simplicity, cost-effectiveness, stability, storability, disposability, and portability. As a result, various designs for different types of assays are developed and investigated. In recent years, µPADs are combined with conventional detection methods to enable rapid on-site detection, providing results comparable to expensive and sophisticated large-scale testing methods that require more time and skilled personnel. The application of µPAD techniques is extensive in environmental quality control/analysis, clinical diagnosis, and food safety testing, paving the way for on-site real-time diagnosis as a promising future development. This review focuses on the recent research advancements in the design, fabrication, material selection, and detection methods of µPADs. It provides a comprehensive understanding of their principles of operation, applications, and future development prospects. © 2024 Wiley-VCH GmbH.
Original languageEnglish
Article number2400155
JournalSmall Methods
Volume8
Issue number11
Online published23 May 2024
DOIs
Publication statusPublished - 20 Nov 2024

Funding

The work described in this paper was supported by a grant from the Shenzhen Fundamental Research Program (JCYJ20190808181607387) and partially by a grant from the Katie Shu Sui Pui Charitable Trust — Research and Publication Fund (KS2021/02), a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (UGC/FDS16/M(P)05/21), a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (UGC/IDS(R)16/19), and a grant from the Hong Kong Metropolitan University Research Grant (PFDS/2023/14).

Research Keywords

  • clinical diagnosis
  • environmental test
  • food safety
  • microfluidics
  • µPAD

Fingerprint

Dive into the research topics of 'Advances in Microfluidic Paper-Based Analytical Devices (µPADs): Design, Fabrication, and Applications'. Together they form a unique fingerprint.

Cite this