Activity-Dependent K+ Accumulation in the Developing Rat Optic Nerve

Barry W. Connors; Bruce R. Ransom; David M. Kunis; Michael J. Gutnick

doi:10.1126/science.7079771

Activity-Dependent K⁺ Accumulation in the Developing Rat Optic Nerve

Barry W. Connors
, Bruce R. Ransom
, David M. Kunis
, Michael J. Gutnick

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

145 Citations (Scopus)

Abstract

Potassium-sensitive microelectrodes were used to study activity-dependent changes of extracellular potassium ion concentration ([K⁺] _o ) in rat optic nerves of different postnatal ages (1 day to adulthood). The maximum level to which [K⁺] _o rose with optimal frequencies of stimulation depended on age: mean maximum evoked [K⁺] _o was 17.2 mM in 1- to 3-day-old optic nerves and 9.8 mM in adult nerves. The ceiling [K⁺] _o seen in immature optic nerves, which is uniquely large for a mammalian central nervous system structure, may result from a relatively enhanced rate of evoked K⁺ release. Copyright © 1982 AAAS.

Original language	English
Pages (from-to)	1341-1343
Journal	Science
Volume	216
Issue number	4552
DOIs	https://doi.org/10.1126/science.7079771
Publication status	Published - 18 Jun 1982
Externally published	Yes

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@article{d6e572e1b10e48adb5fa9f24886a7f9a,

title = "Activity-Dependent K+ Accumulation in the Developing Rat Optic Nerve",

abstract = "Potassium-sensitive microelectrodes were used to study activity-dependent changes of extracellular potassium ion concentration ([K+] o ) in rat optic nerves of different postnatal ages (1 day to adulthood). The maximum level to which [K+] o rose with optimal frequencies of stimulation depended on age: mean maximum evoked [K+] o was 17.2 mM in 1- to 3-day-old optic nerves and 9.8 mM in adult nerves. The ceiling [K+] o seen in immature optic nerves, which is uniquely large for a mammalian central nervous system structure, may result from a relatively enhanced rate of evoked K+ release. Copyright {\textcopyright} 1982 AAAS.",

author = "Connors, \{Barry W.\} and Ransom, \{Bruce R.\} and Kunis, \{David M.\} and Gutnick, \{Michael J.\}",

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AU - Connors, Barry W.

AU - Ransom, Bruce R.

AU - Kunis, David M.

AU - Gutnick, Michael J.

PY - 1982/6/18

Y1 - 1982/6/18

N2 - Potassium-sensitive microelectrodes were used to study activity-dependent changes of extracellular potassium ion concentration ([K+] o ) in rat optic nerves of different postnatal ages (1 day to adulthood). The maximum level to which [K+] o rose with optimal frequencies of stimulation depended on age: mean maximum evoked [K+] o was 17.2 mM in 1- to 3-day-old optic nerves and 9.8 mM in adult nerves. The ceiling [K+] o seen in immature optic nerves, which is uniquely large for a mammalian central nervous system structure, may result from a relatively enhanced rate of evoked K+ release. Copyright © 1982 AAAS.

AB - Potassium-sensitive microelectrodes were used to study activity-dependent changes of extracellular potassium ion concentration ([K+] o ) in rat optic nerves of different postnatal ages (1 day to adulthood). The maximum level to which [K+] o rose with optimal frequencies of stimulation depended on age: mean maximum evoked [K+] o was 17.2 mM in 1- to 3-day-old optic nerves and 9.8 mM in adult nerves. The ceiling [K+] o seen in immature optic nerves, which is uniquely large for a mammalian central nervous system structure, may result from a relatively enhanced rate of evoked K+ release. Copyright © 1982 AAAS.

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M3 - RGC 21 - Publication in refereed journal

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SP - 1341

EP - 1343

JO - Science

JF - Science

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