@inproceedings{853346f18da7488ca072551c85b9e729,
title = "Active Manipulation of ECM Stiffness and Its Effect on Endothelial Cell Migration during Angiogenesis",
abstract = "We have developed an engineering approach for actively manipulating the local stiffness of the extracellular matrix (ECM) and studied its effect on the migration of endothelial cells (ECs). In this approach, magnetic beads are embedded in an ECM through bio-conjugation between the Streptavidin-coated beads and the collagen fibers in order to alter the local stiffness of the ECM with the application of an external magnetic field. Our experimental results show that the magnetic forces acting on the embedded beads influence the behaviour of ECs during angiogenesis. These results suggest the possibility of creating desired stiffness gradients in an ECM for manipulating cell behavior in vitro.",
keywords = "Angiogenesis, Force, Magnetic field, Manipulation, Stiffness",
author = "Chen, {Peter C.Y.} and Herath, {Sahan C.B.} and Dong-an Wang and Harry Asada",
note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to
[email protected].; 2012 World Congress on Engineering (WCE 2012) ; Conference date: 04-07-2012 Through 06-07-2012",
year = "2012",
month = jul,
language = "English",
volume = "1",
series = "Lecture Notes in Engineering and Computer Science",
publisher = "Newswood Limited",
pages = "622--626",
editor = "Ao, {S. I.} and Len Gelman and Hukins, {David WL} and Andrew Hunter and Korsunsky, {A. M.}",
booktitle = "Proceedings of the World Congress on Engineering 2012",
}