Acetone extracts of sea urchin Anthocidaris crassispina stimulate osteogenesis and adipogenesis in mouse mesenchymal stem cells

Hai-Fang Li; Guo-Ping Cai; Meng-Su Yang

doi:10.1109/ICBBE.2010.5517034

Acetone extracts of sea urchin Anthocidaris crassispina stimulate osteogenesis and adipogenesis in mouse mesenchymal stem cells

Hai-Fang Li^*, Guo-Ping Cai, Meng-Su Yang

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

In this study, it was found that the acetone extracts of Anthocidaris crassispina could stimulate both osteogenesis and adipogenesis in mouse mesenchymal stem cells (MSCs). The sea urchin was disparted into three parts: shell, spindle and gonad (Sh, Sp and G in short, respectively), and extracted with acetone. Either with or without inducers, Sp and G at concentrations of 0.2 or 0.5 mg/ml remarkably stimulated the ALP activity and the formation of fat droplets in MSC osteogenesis and adipogenesis, respectively. However, Sh displayed no significant effect on either of the differentiations. Moreover, the expression levels of Runx2 and PPARγ2 were also up-regulated upon Sp and G treatments significantly, but not with Sh treatment. Our study demonstrated for the first time that the Sp and G from A. crassispina may be beneficial in the prevention of some bone related diseases and insulin resistance via its potency to stimulate osteogenesis and adipogenesis of MSCs. © 2010 IEEE.

Original language	English
Title of host publication	2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010
DOIs	https://doi.org/10.1109/ICBBE.2010.5517034
Publication status	Published - 2010
Event	4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2010) - Chengdu, China Duration: 18 Jun 2010 → 20 Jun 2010

Conference

Conference	4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2010)
Place	China
City	Chengdu
Period	18/06/10 → 20/06/10

Research Keywords

Adipogenesis
Anthocidaris crassispina
Mouse mesenchymal stem cells (mscs)
Osteogenesis

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10.1109/ICBBE.2010.5517034

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@inproceedings{5e0dd5fec7354a5cabf75533042e751e,

title = "Acetone extracts of sea urchin Anthocidaris crassispina stimulate osteogenesis and adipogenesis in mouse mesenchymal stem cells",

abstract = "In this study, it was found that the acetone extracts of Anthocidaris crassispina could stimulate both osteogenesis and adipogenesis in mouse mesenchymal stem cells (MSCs). The sea urchin was disparted into three parts: shell, spindle and gonad (Sh, Sp and G in short, respectively), and extracted with acetone. Either with or without inducers, Sp and G at concentrations of 0.2 or 0.5 mg/ml remarkably stimulated the ALP activity and the formation of fat droplets in MSC osteogenesis and adipogenesis, respectively. However, Sh displayed no significant effect on either of the differentiations. Moreover, the expression levels of Runx2 and PPARγ2 were also up-regulated upon Sp and G treatments significantly, but not with Sh treatment. Our study demonstrated for the first time that the Sp and G from A. crassispina may be beneficial in the prevention of some bone related diseases and insulin resistance via its potency to stimulate osteogenesis and adipogenesis of MSCs. {\textcopyright} 2010 IEEE.",

keywords = "Adipogenesis, Anthocidaris crassispina, Mouse mesenchymal stem cells (mscs), Osteogenesis",

author = "Hai-Fang Li and Guo-Ping Cai and Meng-Su Yang",

year = "2010",

doi = "10.1109/ICBBE.2010.5517034",

language = "English",

isbn = "9781424447138",

booktitle = "2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010",

note = "4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2010) ; Conference date: 18-06-2010 Through 20-06-2010",

}

Li, H-F, Cai, G-P & Yang, M-S 2010, Acetone extracts of sea urchin Anthocidaris crassispina stimulate osteogenesis and adipogenesis in mouse mesenchymal stem cells. in 2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010., 5517034, 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2010) , Chengdu, China, 18/06/10. https://doi.org/10.1109/ICBBE.2010.5517034

Acetone extracts of sea urchin Anthocidaris crassispina stimulate osteogenesis and adipogenesis in mouse mesenchymal stem cells. / Li, Hai-Fang; Cai, Guo-Ping; Yang, Meng-Su.
2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010. 2010. 5517034.

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - Acetone extracts of sea urchin Anthocidaris crassispina stimulate osteogenesis and adipogenesis in mouse mesenchymal stem cells

AU - Li, Hai-Fang

AU - Cai, Guo-Ping

AU - Yang, Meng-Su

PY - 2010

Y1 - 2010

N2 - In this study, it was found that the acetone extracts of Anthocidaris crassispina could stimulate both osteogenesis and adipogenesis in mouse mesenchymal stem cells (MSCs). The sea urchin was disparted into three parts: shell, spindle and gonad (Sh, Sp and G in short, respectively), and extracted with acetone. Either with or without inducers, Sp and G at concentrations of 0.2 or 0.5 mg/ml remarkably stimulated the ALP activity and the formation of fat droplets in MSC osteogenesis and adipogenesis, respectively. However, Sh displayed no significant effect on either of the differentiations. Moreover, the expression levels of Runx2 and PPARγ2 were also up-regulated upon Sp and G treatments significantly, but not with Sh treatment. Our study demonstrated for the first time that the Sp and G from A. crassispina may be beneficial in the prevention of some bone related diseases and insulin resistance via its potency to stimulate osteogenesis and adipogenesis of MSCs. © 2010 IEEE.

AB - In this study, it was found that the acetone extracts of Anthocidaris crassispina could stimulate both osteogenesis and adipogenesis in mouse mesenchymal stem cells (MSCs). The sea urchin was disparted into three parts: shell, spindle and gonad (Sh, Sp and G in short, respectively), and extracted with acetone. Either with or without inducers, Sp and G at concentrations of 0.2 or 0.5 mg/ml remarkably stimulated the ALP activity and the formation of fat droplets in MSC osteogenesis and adipogenesis, respectively. However, Sh displayed no significant effect on either of the differentiations. Moreover, the expression levels of Runx2 and PPARγ2 were also up-regulated upon Sp and G treatments significantly, but not with Sh treatment. Our study demonstrated for the first time that the Sp and G from A. crassispina may be beneficial in the prevention of some bone related diseases and insulin resistance via its potency to stimulate osteogenesis and adipogenesis of MSCs. © 2010 IEEE.

KW - Adipogenesis

KW - Anthocidaris crassispina

KW - Mouse mesenchymal stem cells (mscs)

KW - Osteogenesis

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U2 - 10.1109/ICBBE.2010.5517034

DO - 10.1109/ICBBE.2010.5517034

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781424447138

BT - 2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010

T2 - 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2010)

Y2 - 18 June 2010 through 20 June 2010

ER -

Acetone extracts of sea urchin Anthocidaris crassispina stimulate osteogenesis and adipogenesis in mouse mesenchymal stem cells

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