TY - GEN
T1 - Accurate Cell Segmentation Based on Biological Morphology Features
AU - Cao, Jianfeng
AU - Zhao, Zhongying
AU - Yan, Hong
PY - 2018/10
Y1 - 2018/10
N2 - Microscopic imaging has many applications in biological experiments. It is important to determine the cell locations in an image before other analysis tasks take place. In this paper, we propose a novel method to obtain cell and membrane segmentation based on the combination of k nearest neighbor clustering and biological morphology constraints. First, we produce preliminary segmentation with the watershed transformation. Then the segmentation results are optimized based on the morphological characteristics of the membrane. This method provides us with well-segmented cells and membranes, which significantly reduces errors in cell image analysis.
AB - Microscopic imaging has many applications in biological experiments. It is important to determine the cell locations in an image before other analysis tasks take place. In this paper, we propose a novel method to obtain cell and membrane segmentation based on the combination of k nearest neighbor clustering and biological morphology constraints. First, we produce preliminary segmentation with the watershed transformation. Then the segmentation results are optimized based on the morphological characteristics of the membrane. This method provides us with well-segmented cells and membranes, which significantly reduces errors in cell image analysis.
KW - cell and membrane segmentation
KW - biological constraints
KW - nearest neighbor clustering
UR - http://www.scopus.com/inward/record.url?scp=85062220030&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85062220030&origin=recordpage
U2 - 10.1109/SMC.2018.00572
DO - 10.1109/SMC.2018.00572
M3 - RGC 32 - Refereed conference paper (with host publication)
T3 - IEEE International Conference on Systems Man and Cybernetics Conference Proceedings
SP - 3380
EP - 3383
BT - Proceedings - 2018 IEEE International Conference on Systems, Man, and Cybernetics (SMC 2018)
PB - IEEE
T2 - IEEE International Conference on Systems, Man, and Cybernetics (SMC)
Y2 - 7 October 2018 through 10 October 2018
ER -