Abolition of endothelium-dependent relaxation in the rat aorta by tetraoctylammonium ions

Y. Huang; X. Q. Yao; F. L. Chan; C. W. Lau; N. W.K. Chan; Z. Y. Chen

doi:10.1007/s002100000278

Abolition of endothelium-dependent relaxation in the rat aorta by tetraoctylammonium ions

Y. Huang, X. Q. Yao, F. L. Chan, C. W. Lau, N. W.K. Chan, Z. Y. Chen

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

3 Citations (Scopus)

Abstract

Quaternary ammonium ions are common pharmacological probes used to study the kinetic properties of K⁺ channels in smooth muscle cells. On the other hand, some ammonium compounds cause vasorelaxation through unknown mechanisms. The main aim of this study was to examine a unique role of endothelium in the vascular response to tetraoctylammonium ions (TOA⁺) in the isolated rat aorta. Changes in contractile force were measured by force transducers and total tissue content of cGMP was measured by radioimmunoassay. Endothelial cytosolic Ca²⁺ ([Ca²⁺](i)) was assessed by laser scanning confocal microscopy.

Original language	English
Pages (from-to)	152-159
Journal	Naunyn-Schmiedeberg's Archives of Pharmacology
Volume	362
Issue number	2
DOIs	https://doi.org/10.1007/s002100000278
Publication status	Published - 2000
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

Aorta
Cyclic GMP
Endothelium
Nitric oxide
Rat
Relaxation
Tetraoctylammonium ions

Access Output

10.1007/s002100000278

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{1c22dc0de9d344d4a4b7afc95f6d4b59,

title = "Abolition of endothelium-dependent relaxation in the rat aorta by tetraoctylammonium ions",

abstract = "Quaternary ammonium ions are common pharmacological probes used to study the kinetic properties of K+ channels in smooth muscle cells. On the other hand, some ammonium compounds cause vasorelaxation through unknown mechanisms. The main aim of this study was to examine a unique role of endothelium in the vascular response to tetraoctylammonium ions (TOA+) in the isolated rat aorta. Changes in contractile force were measured by force transducers and total tissue content of cGMP was measured by radioimmunoassay. Endothelial cytosolic Ca2+ ([Ca2+](i)) was assessed by laser scanning confocal microscopy.",

keywords = "Aorta, Cyclic GMP, Endothelium, Nitric oxide, Rat, Relaxation, Tetraoctylammonium ions",

author = "Y. Huang and Yao, {X. Q.} and Chan, {F. L.} and Lau, {C. W.} and Chan, {N. W.K.} and Chen, {Z. Y.}",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].",

year = "2000",

doi = "10.1007/s002100000278",

language = "English",

volume = "362",

pages = "152--159",

journal = "Naunyn-Schmiedeberg's Archives of Pharmacology",

issn = "0028-1298",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "2",

}

TY - JOUR

T1 - Abolition of endothelium-dependent relaxation in the rat aorta by tetraoctylammonium ions

AU - Huang, Y.

AU - Yao, X. Q.

AU - Chan, F. L.

AU - Lau, C. W.

AU - Chan, N. W.K.

AU - Chen, Z. Y.

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2000

Y1 - 2000

N2 - Quaternary ammonium ions are common pharmacological probes used to study the kinetic properties of K+ channels in smooth muscle cells. On the other hand, some ammonium compounds cause vasorelaxation through unknown mechanisms. The main aim of this study was to examine a unique role of endothelium in the vascular response to tetraoctylammonium ions (TOA+) in the isolated rat aorta. Changes in contractile force were measured by force transducers and total tissue content of cGMP was measured by radioimmunoassay. Endothelial cytosolic Ca2+ ([Ca2+](i)) was assessed by laser scanning confocal microscopy.

AB - Quaternary ammonium ions are common pharmacological probes used to study the kinetic properties of K+ channels in smooth muscle cells. On the other hand, some ammonium compounds cause vasorelaxation through unknown mechanisms. The main aim of this study was to examine a unique role of endothelium in the vascular response to tetraoctylammonium ions (TOA+) in the isolated rat aorta. Changes in contractile force were measured by force transducers and total tissue content of cGMP was measured by radioimmunoassay. Endothelial cytosolic Ca2+ ([Ca2+](i)) was assessed by laser scanning confocal microscopy.

KW - Aorta

KW - Cyclic GMP

KW - Endothelium

KW - Nitric oxide

KW - Rat

KW - Relaxation

KW - Tetraoctylammonium ions

UR - http://www.scopus.com/inward/record.url?scp=0033890218&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-0033890218&origin=recordpage

U2 - 10.1007/s002100000278

DO - 10.1007/s002100000278

M3 - RGC 21 - Publication in refereed journal

C2 - 10961378

SN - 0028-1298

VL - 362

SP - 152

EP - 159

JO - Naunyn-Schmiedeberg's Archives of Pharmacology

JF - Naunyn-Schmiedeberg's Archives of Pharmacology

IS - 2

ER -

Abolition of endothelium-dependent relaxation in the rat aorta by tetraoctylammonium ions

Abstract

Bibliographical note

Research Keywords

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Cite this