A zipped-up tunable metal coordinated cationic polymer for nanomedicine

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

1 Scopus Citations
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Author(s)

  • Jianming Mao
  • Jianwei Wang
  • Guping Tang
  • Paul K. Chu
  • Hongzhen Bai

Detail(s)

Original languageEnglish
Pages (from-to)1350-1358
Journal / PublicationJournal of Materials Chemistry B
Volume8
Issue number7
Online published30 Jan 2020
Publication statusPublished - 21 Feb 2020

Abstract

Incorporating metal elements into polymers is a feasible means to fabricate new materials with multiple functionalities. In this work, a metal coordinated cationic polymer (MCCP) was developed. Ferric ions were incorporated into the polyethyleneimine-β-cyclodextrin (PC) polymer chain via coordination to produce a zipped-up polymer with a micro-ordered and macro-disordered topological structure. By varying the metal concentration, a tunable superstructure could be formed on the nanolates via the "zipping" effect. In addition, the physicochemical properties of the assembly of MCCPs and nucleic acids were tailored by tuning the composition of the metal ions and polymers. The loading efficiency of Rhodamine-B by MCCPs was enhanced. The in vitro and in vivo results showed that the hybrid materials could be adjusted to deliver nucleic acids or small molecules with good performance and acquired the capacity of generating reactive oxygen species in tumor cells. Thus, the tunable and multifunctional MCCP system has great potential in nanomedicine and biomaterial science.

Citation Format(s)

A zipped-up tunable metal coordinated cationic polymer for nanomedicine. / Mao, Jianming; Wang, Jianwei; Tang, Guping; Chu, Paul K.; Bai, Hongzhen.

In: Journal of Materials Chemistry B, Vol. 8, No. 7, 21.02.2020, p. 1350-1358.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review