A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations 

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

14 Scopus Citations
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Author(s)

  • José Francisco Lima-Barbero
  • Marinela Contreras
  • Lourdes Mateos-Hernández
  • Francisco Manuel Mata-Lorenzo
  • Roxana Triguero-Ocaña
  • Robert D. Finn
  • Christina Strube
  • Daniel R.G. Price
  • Francesca Nunn
  • Kathryn Bartley
  • Ursula Höfle
  • Mariana Boadella
  • Alasdair J. Nisbet
  • José de la Fuente
  • Margarita Villar

Detail(s)

Original languageEnglish
Article number190
Journal / PublicationVaccines
Volume7
Issue number4
Online published20 Nov 2019
Publication statusPublished - Dec 2019

Link(s)

Abstract

The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. Rhipicephalus microplus Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens for the PRM control.

Research Area(s)

  • Control, Dermanyssus, Poultry red mite, Protective antigens, Proteomics, Vaccine, Vaccinology

Citation Format(s)

A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations . / Lima-Barbero, José Francisco; Contreras, Marinela; Mateos-Hernández, Lourdes et al.
In: Vaccines, Vol. 7, No. 4, 190, 12.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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