A universal biosensing platform based on optical micro-ring resonators

A. Ramachandran; S. Wang; J. Clarke; S. J. Ja; D. Goad; L. Wald; E. M. Flood; E. Knobbe; J. V. Hryniewicz; S. T. Chu; D. Gill; W. Chen; O. King; B. E. Little

doi:10.1016/j.bios.2007.09.007

A universal biosensing platform based on optical micro-ring resonators

A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, B. E. Little

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

224 Citations (Scopus)

Abstract

The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids. © 2007 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	939-944
Journal	Biosensors and Bioelectronics
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.bios.2007.09.007
Publication status	Published - 28 Feb 2008
Externally published	Yes

Research Keywords

Antibody
Antigen
Bacteria
Biosensor
IgG
IgM
Label-free quantitative detection
Micro-ring resonators
Nucleic acid
Optical resonators
Whole cell detection

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10.1016/j.bios.2007.09.007

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title = "A universal biosensing platform based on optical micro-ring resonators",

abstract = "The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids. {\textcopyright} 2007 Elsevier B.V. All rights reserved.",

keywords = "Antibody, Antigen, Bacteria, Biosensor, IgG, IgM, Label-free quantitative detection, Micro-ring resonators, Nucleic acid, Optical resonators, Whole cell detection",

author = "A. Ramachandran and S. Wang and J. Clarke and Ja, {S. J.} and D. Goad and L. Wald and Flood, {E. M.} and E. Knobbe and Hryniewicz, {J. V.} and Chu, {S. T.} and D. Gill and W. Chen and O. King and Little, {B. E.}",

year = "2008",

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doi = "10.1016/j.bios.2007.09.007",

language = "English",

volume = "23",

pages = "939--944",

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issn = "0956-5663",

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TY - JOUR

T1 - A universal biosensing platform based on optical micro-ring resonators

AU - Ramachandran, A.

AU - Wang, S.

AU - Clarke, J.

AU - Ja, S. J.

AU - Goad, D.

AU - Wald, L.

AU - Flood, E. M.

AU - Knobbe, E.

AU - Hryniewicz, J. V.

AU - Chu, S. T.

AU - Gill, D.

AU - Chen, W.

AU - King, O.

AU - Little, B. E.

PY - 2008/2/28

Y1 - 2008/2/28

N2 - The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids. © 2007 Elsevier B.V. All rights reserved.

AB - The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids. © 2007 Elsevier B.V. All rights reserved.

KW - Antibody

KW - Antigen

KW - Bacteria

KW - Biosensor

KW - IgG

KW - IgM

KW - Label-free quantitative detection

KW - Micro-ring resonators

KW - Nucleic acid

KW - Optical resonators

KW - Whole cell detection

UR - http://www.scopus.com/inward/record.url?scp=38749109658&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-38749109658&origin=recordpage

U2 - 10.1016/j.bios.2007.09.007

DO - 10.1016/j.bios.2007.09.007

M3 - RGC 21 - Publication in refereed journal

C2 - 17964774

SN - 0956-5663

VL - 23

SP - 939

EP - 944

JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

IS - 7

ER -

A universal biosensing platform based on optical micro-ring resonators

Abstract

Research Keywords

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