A Trinuclear Heterobimetallic Ru(II)/Pt(II) Complex as a Chemodosimeter Selective for Sulfhydryl-Containing Amino Acids and Peptides

Cheuk-Fai Chow; Brenda K. W. Chiu; Michael H. W. Lam; Wai-Yeung Wong

doi:10.1021/ja034891x

A Trinuclear Heterobimetallic Ru(II)/Pt(II) Complex as a Chemodosimeter Selective for Sulfhydryl-Containing Amino Acids and Peptides

Cheuk-Fai Chow, Brenda K. W. Chiu, Michael H. W. Lam, Wai-Yeung Wong

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

128 Citations (Scopus)

Abstract

A trinuclear heterobimetallic Ru(II)/Pt(II) complex, cis-{Ru(phen)₂[CN-Pt(DMSO)Cl₂]₂} (phen = 1,10-phenanthroline), is able to function as a "switch-on" luminescent chemodosimeter for sulfhydryl-containing amino acids and peptides via specific binding of the amino acids/peptides with the Pt(II) centers and the subsequent cleavage of the Ru(II)-Pt(II) cyano-bridge.

Original language	English
Pages (from-to)	7802-7803
Journal	Journal of the American Chemical Society
Volume	125
Issue number	26
Online published	4 Jun 2003
DOIs	https://doi.org/10.1021/ja034891x
Publication status	Published - 2 Jul 2003

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title = "A Trinuclear Heterobimetallic Ru(II)/Pt(II) Complex as a Chemodosimeter Selective for Sulfhydryl-Containing Amino Acids and Peptides",

abstract = "A trinuclear heterobimetallic Ru(II)/Pt(II) complex, cis-{Ru(phen)2[CN-Pt(DMSO)Cl2]2} (phen = 1,10-phenanthroline), is able to function as a {"}switch-on{"} luminescent chemodosimeter for sulfhydryl-containing amino acids and peptides via specific binding of the amino acids/peptides with the Pt(II) centers and the subsequent cleavage of the Ru(II)-Pt(II) cyano-bridge.",

author = "Cheuk-Fai Chow and Chiu, {Brenda K. W.} and Lam, {Michael H. W.} and Wai-Yeung Wong",

year = "2003",

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doi = "10.1021/ja034891x",

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A Trinuclear Heterobimetallic Ru(II)/Pt(II) Complex as a Chemodosimeter Selective for Sulfhydryl-Containing Amino Acids and Peptides. / Chow, Cheuk-Fai; Chiu, Brenda K. W.; Lam, Michael H. W. et al.
In: Journal of the American Chemical Society, Vol. 125, No. 26, 02.07.2003, p. 7802-7803.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - A Trinuclear Heterobimetallic Ru(II)/Pt(II) Complex as a Chemodosimeter Selective for Sulfhydryl-Containing Amino Acids and Peptides

AU - Chow, Cheuk-Fai

AU - Chiu, Brenda K. W.

AU - Lam, Michael H. W.

AU - Wong, Wai-Yeung

PY - 2003/7/2

Y1 - 2003/7/2

N2 - A trinuclear heterobimetallic Ru(II)/Pt(II) complex, cis-{Ru(phen)2[CN-Pt(DMSO)Cl2]2} (phen = 1,10-phenanthroline), is able to function as a "switch-on" luminescent chemodosimeter for sulfhydryl-containing amino acids and peptides via specific binding of the amino acids/peptides with the Pt(II) centers and the subsequent cleavage of the Ru(II)-Pt(II) cyano-bridge.

AB - A trinuclear heterobimetallic Ru(II)/Pt(II) complex, cis-{Ru(phen)2[CN-Pt(DMSO)Cl2]2} (phen = 1,10-phenanthroline), is able to function as a "switch-on" luminescent chemodosimeter for sulfhydryl-containing amino acids and peptides via specific binding of the amino acids/peptides with the Pt(II) centers and the subsequent cleavage of the Ru(II)-Pt(II) cyano-bridge.

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U2 - 10.1021/ja034891x

DO - 10.1021/ja034891x

M3 - RGC 21 - Publication in refereed journal

C2 - 12822989

SN - 0002-7863

VL - 125

SP - 7802

EP - 7803

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 26

ER -

A Trinuclear Heterobimetallic Ru(II)/Pt(II) Complex as a Chemodosimeter Selective for Sulfhydryl-Containing Amino Acids and Peptides

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