A three-dimensional quasicontinuum approach for predicting biomechanical properties of malaria-infected red blood cell membrane

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

3 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)35-47
Journal / PublicationApplied Mathematical Modelling
Volume49
Early online date3 May 2017
Publication statusPublished - Sep 2017

Abstract

This paper presents the first attempt to comprehensively estimate the elastic properties and mechanical responses of malaria-infected red blood cell (iRBC) membrane when subjected to uniaxial, shear and isotropic area-dilation loading conditions. With the threedimensional (3D) quasicontinuum approach, we predicted the biomechanical properties of the iRBC membrane for all infection stages. Effect of temperature on the membrane elastic properties during the trophozoite stage was also examined. It is found that a multifold increase in the elastic properties of the iRBC membrane occurs as infection progresses. The axial, shear and area stiffnesses of the iRBC membrane increase exponentially, resulting in semi-logarithmic stress–strain relationship curves. In addition, the rigidity of the iRBC membrane in the trophozoite stage increases as temperature rise. It is concluded that Plasmodium falciparum parasites significantly affect the biomechanical properties of the RBC membrane due to the structural remodeling of the iRBC membrane microstructure.

Research Area(s)

  • Elastomechanical properties, Multiscale Cauchy–Born modeling, Plasmodium falciparum, RBC membrane microstructure, Stress–strain curves, Temperature effect