Abstract
In a recent study, Sauvé et al. identified hypothalamic tanycytes as a route for tau transport from cerebrospinal fluid to blood and suggested that disruption of this pathway contributes to Alzheimer's disease pathology. The work broadens current models of tau clearance and raises new questions about how tanycytic dysfunction contributes to neurodegeneration. © 2026 Elsevier Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 326-327 |
| Journal | Trends in Neurosciences |
| Volume | 49 |
| Issue number | 5 |
| Online published | 18 Apr 2026 |
| DOIs | |
| Publication status | Published - May 2026 |
Bibliographical note
Copyright © 2026 Elsevier Ltd. All rights reserved.Funding
C.H. is supported by a Race Against Dementia Fellowship, Alzheimer’s Research UK (ARUK-RADF2019A007), Alzheimer’s Research UK Senior Fellowship (ARUK-SRF2023A-001), and Herbalgy Presidential Associate Professorship.
Research Keywords
- tanycyte
- tauopathies
- dementia
- blood–brain barrier
- neurodegeneration
- brain clearance
Fingerprint
Dive into the research topics of 'A tanycytic route for tau clearance in Alzheimer's disease'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver