A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
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Pages (from-to) | 421-430 |
Journal / Publication | Acta Biomaterialia |
Volume | 114 |
Online published | 22 Jul 2020 |
Publication status | Published - 15 Sept 2020 |
Link(s)
Abstract
Implant-associated infections is one of the most challenging post-operative complications in bone-related implantations. To tackle this clinical issue, we developed a low-cost and durable surface coating for medical grade titanium implants that uses positively charged silane molecules. The in vitro antimicrobial tests revealed that the titanium surface coated with (3-aminopropyl) triethoxysilane, which has the appropriate length of hydrophobic alkyl chain and positive charged amino group, suppressed more than 90% of the initial bacterial adhesion of S. aureus, P. aeruginosa, and E. coli after 30 min of incubation. In terms of growth inhibitory rate, the treated surface was able to reduce 75.7% ± 11.9% of bacterial growth after a 24-hour culturing, thereby exhibiting superior anti-biofilm formation in the late stage. When implanted into the rat model infected by S. aureus, the treated surface eliminated the implant-associated infection through the mechanism of inhibition of bacterial adhesion on the implant surface. Additionally, the treated surface was highly compatible with mammalian cells. In general, our design demonstrated its potential for human clinical trials as a low-cost and effective antibacterial strategy to minimize post-operative implant-related bacterial infection.
Research Area(s)
- Antimicrobial property, Biocompatibility, Orthopedic implant, Surface modification, Titanium alloy
Citation Format(s)
A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections. / Shen, Jie; Gao, Peng; Han, Shan et al.
In: Acta Biomaterialia, Vol. 114, 15.09.2020, p. 421-430.
In: Acta Biomaterialia, Vol. 114, 15.09.2020, p. 421-430.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review