TY - JOUR
T1 - A simple regulatory circuit that can simultaneously generate excitability of two different mechanisms
AU - Shi, Changhong
AU - Li, Han-Xiong
AU - Zhou, Tianshou
PY - 2012/1
Y1 - 2012/1
N2 - Coupled positive and negative feedback loops occur in many cellular signaling systems. We show that a two-component circuit with this kind of network structure can simultaneously generate excitability of two different mechanisms that is similar to either integrator or resonator in neuroscience. Moreover, we find that there is an opposite tendency between switching frequencies in the two excitable mechanisms, and the duration and amplitude of the response spike are more resistant to noise in the integrate system than in the resonate system. In addition, we discuss, combining the Bacillis subtilis model organism, some possible biological implications of these differences.
AB - Coupled positive and negative feedback loops occur in many cellular signaling systems. We show that a two-component circuit with this kind of network structure can simultaneously generate excitability of two different mechanisms that is similar to either integrator or resonator in neuroscience. Moreover, we find that there is an opposite tendency between switching frequencies in the two excitable mechanisms, and the duration and amplitude of the response spike are more resistant to noise in the integrate system than in the resonate system. In addition, we discuss, combining the Bacillis subtilis model organism, some possible biological implications of these differences.
KW - Excitability
KW - Feedback
KW - Integrator
KW - Resonator
UR - http://www.scopus.com/inward/record.url?scp=83455163743&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-83455163743&origin=recordpage
U2 - 10.3934/dcdsb.2012.17.271
DO - 10.3934/dcdsb.2012.17.271
M3 - RGC 21 - Publication in refereed journal
SN - 1531-3492
VL - 17
SP - 271
EP - 282
JO - Discrete and Continuous Dynamical Systems - Series B
JF - Discrete and Continuous Dynamical Systems - Series B
IS - 1
ER -