A simple model for quantification of the radiobiological effectiveness of the 10B(n,α)7Li capture reaction in BNCT

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • C. H. Hsieh
  • H. M. Liu
  • J. J. Hwang
  • H. E. Wang
  • F. D. Chen

Detail(s)

Original languageEnglish
Pages (from-to)306-314
Journal / PublicationApplied Radiation and Isotopes
Volume64
Issue number3
Publication statusPublished - Mar 2006
Externally publishedYes

Abstract

A simple model has been developed for predicting radiobiological effectiveness of the neutron capture reaction in boron neutron capture therapy. This model was derived from the relationship between the cell survival from the boron capture reaction, the intracellular boron concentration, and the thermal neutron fluence. We found that the cell-killing effect of the boron capture reaction was well described using a power function of the intracellular boron concentration. Hence the relationship between cell survival from the boron capture reaction, intracellular boron concentration, and the thermal neutron fluence could be determined using a simple mathematical equation. We consider that our current approach is more appropriate and realistic than the conventional theoretical mathematical model used to estimate the radiobiological effectiveness of the neutron capture reaction in boron neutron capture therapy. © 2005 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Boron neutron capture therapy (BNCT), BPA-Fr, F98 glioma

Citation Format(s)

A simple model for quantification of the radiobiological effectiveness of the 10B(n,α)7Li capture reaction in BNCT. / Hsieh, C. H.; Liu, H. M.; Hwang, J. J. et al.
In: Applied Radiation and Isotopes, Vol. 64, No. 3, 03.2006, p. 306-314.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review