Abstract
Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug-loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post-fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm−2. Additional post-fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies.
| Original language | English |
|---|---|
| Article number | e10157 |
| Journal | Bioengineering and Translational Medicine |
| Volume | 5 |
| Issue number | 2 |
| Online published | 21 Feb 2020 |
| DOIs | |
| Publication status | Published - May 2020 |
| Externally published | Yes |
Research Keywords
- bioadhesive
- dendrimer
- microneedles
- self-adhesive
- transdermal drug delivery
Publisher's Copyright Statement
- This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/
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