A selective HIV-1 RNA G-quadruplex-targeting L-aptamer–D-antisense conjugate inhibits HIV-1 minus strand transfer
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 13558-13561 |
| Journal / Publication | Chemical Communications |
| Volume | 60 |
| Issue number | 92 |
| Online published | 30 Oct 2024 |
| Publication status | Published - 28 Nov 2024 |
Link(s)
Abstract
Herein, we develop an L-RNA aptamer, L-Apt.T8, for recognizing HIV-1 U3-III RNA G-quadruplex, and conjugate the L-Apt.T8 with DNA antisense (L-Apt.T8-10D) to enhance the binding affinity and selectivity. We demonstrate that L-Apt.T8-10D can inhibit HIV-1 U3-tRNA segment complementary binding and nucleocapsid interaction, and interrupt in vitro HIV-1 minus strand transfer. © The Royal Society of Chemistry 2024.
Research Area(s)
Citation Format(s)
A selective HIV-1 RNA G-quadruplex-targeting L-aptamer–D-antisense conjugate inhibits HIV-1 minus strand transfer. / Feng, Hengxin; Kwok, Chun Kit.
In: Chemical Communications, Vol. 60, No. 92, 28.11.2024, p. 13558-13561.
In: Chemical Communications, Vol. 60, No. 92, 28.11.2024, p. 13558-13561.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
