A review on microbial products and their perspective application as antimicrobial agents

Alka Rani; Khem Chand Saini; Felix Bast; Sunita Varjani; Sanjeet Mehariya; Shashi Kant Bhatia; Neeta Sharma; Christiane Funk

doi:10.3390/biom11121860

A review on microbial products and their perspective application as antimicrobial agents

Alka Rani, Khem Chand Saini, Felix Bast^*, Sunita Varjani, Sanjeet Mehariya^*, Shashi Kant Bhatia^*, Neeta Sharma, Christiane Funk

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

50 Citations (Scopus)

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Abstract

Microorganisms including actinomycetes, archaea, bacteria, fungi, yeast, and microalgae are an auspicious source of vital bioactive compounds. In this review, the existing research regarding antimicrobial molecules from microorganisms is summarized. The potential antimicrobial compounds from actinomycetes, particularly Streptomyces spp.; archaea; fungi including endophytic, filamentous, and marine-derived fungi, mushroom; and microalgae are briefly described. Further-more, this review briefly summarizes bacteriocins, halocins, sulfolobicin, etc., that target multiple-drug resistant pathogens and considers next-generation antibiotics. This review highlights the possibility of using microorganisms as an antimicrobial resource for biotechnological, nutraceutical, and pharmaceutical applications. However, more investigations are required to isolate, separate, purify, and characterize these bioactive compounds and transfer these primary drugs into clinically approved antibiotics.

© 2021 by the authors.

Original language	English
Article number	1860
Journal	Biomolecules
Volume	11
Issue number	12
Online published	10 Dec 2021
DOIs	https://doi.org/10.3390/biom11121860
Publication status	Published - Dec 2021
Externally published	Yes

Funding

This research has received funding from the Swedish Research council FORMAS (grant no. 2019-00492).

Research Keywords

Bacteriocins
Chlorellin
Filamentous fungi
Halocin
Lipopeptides
Microalgae

Publisher's Copyright Statement

This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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abstract = "Microorganisms including actinomycetes, archaea, bacteria, fungi, yeast, and microalgae are an auspicious source of vital bioactive compounds. In this review, the existing research regarding antimicrobial molecules from microorganisms is summarized. The potential antimicrobial compounds from actinomycetes, particularly Streptomyces spp.; archaea; fungi including endophytic, filamentous, and marine-derived fungi, mushroom; and microalgae are briefly described. Further-more, this review briefly summarizes bacteriocins, halocins, sulfolobicin, etc., that target multiple-drug resistant pathogens and considers next-generation antibiotics. This review highlights the possibility of using microorganisms as an antimicrobial resource for biotechnological, nutraceutical, and pharmaceutical applications. However, more investigations are required to isolate, separate, purify, and characterize these bioactive compounds and transfer these primary drugs into clinically approved antibiotics.{\textcopyright} 2021 by the authors.",

keywords = "Bacteriocins, Chlorellin, Filamentous fungi, Halocin, Lipopeptides, Microalgae",

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AU - Rani, Alka

AU - Saini, Khem Chand

AU - Bast, Felix

AU - Varjani, Sunita

AU - Mehariya, Sanjeet

AU - Bhatia, Shashi Kant

AU - Sharma, Neeta

AU - Funk, Christiane

PY - 2021/12

Y1 - 2021/12

N2 - Microorganisms including actinomycetes, archaea, bacteria, fungi, yeast, and microalgae are an auspicious source of vital bioactive compounds. In this review, the existing research regarding antimicrobial molecules from microorganisms is summarized. The potential antimicrobial compounds from actinomycetes, particularly Streptomyces spp.; archaea; fungi including endophytic, filamentous, and marine-derived fungi, mushroom; and microalgae are briefly described. Further-more, this review briefly summarizes bacteriocins, halocins, sulfolobicin, etc., that target multiple-drug resistant pathogens and considers next-generation antibiotics. This review highlights the possibility of using microorganisms as an antimicrobial resource for biotechnological, nutraceutical, and pharmaceutical applications. However, more investigations are required to isolate, separate, purify, and characterize these bioactive compounds and transfer these primary drugs into clinically approved antibiotics.© 2021 by the authors.

AB - Microorganisms including actinomycetes, archaea, bacteria, fungi, yeast, and microalgae are an auspicious source of vital bioactive compounds. In this review, the existing research regarding antimicrobial molecules from microorganisms is summarized. The potential antimicrobial compounds from actinomycetes, particularly Streptomyces spp.; archaea; fungi including endophytic, filamentous, and marine-derived fungi, mushroom; and microalgae are briefly described. Further-more, this review briefly summarizes bacteriocins, halocins, sulfolobicin, etc., that target multiple-drug resistant pathogens and considers next-generation antibiotics. This review highlights the possibility of using microorganisms as an antimicrobial resource for biotechnological, nutraceutical, and pharmaceutical applications. However, more investigations are required to isolate, separate, purify, and characterize these bioactive compounds and transfer these primary drugs into clinically approved antibiotics.© 2021 by the authors.

KW - Bacteriocins

KW - Chlorellin

KW - Filamentous fungi

KW - Halocin

KW - Lipopeptides

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DO - 10.3390/biom11121860

M3 - RGC 21 - Publication in refereed journal

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VL - 11

JO - Biomolecules

JF - Biomolecules

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ER -

A review on microbial products and their perspective application as antimicrobial agents

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

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