TY - GEN
T1 - A regulatory network of G2/M phase transition for DNA damage
AU - Zhang, L. W.
AU - Liew, K. M.
PY - 2014
Y1 - 2014
N2 - A regulatory network of G2/M phase transition influenced by different intensities of DNA damage is modeled. It contains the sub-modules of P53-Mdm2 feedback loop and G2/M phase transition process. To investigate the robustness of the regulatory network, a sensitivity analysis of kinetic parameters in the proposed mathematical model is implemented to select the most significant kinetic parameters, which are relevant to key proteins involved in G2/M phase transition. Subsequently, the statistical hypothesis testing is employed to evaluate the influence of perturbations on the G2/M regulatory network. The results indicate that G2/M regulatory network is robust to DNA damage signal when perturbations are very small that is consistent with the experimental observations. © (2014) Trans Tech Publications, Switzerland.
AB - A regulatory network of G2/M phase transition influenced by different intensities of DNA damage is modeled. It contains the sub-modules of P53-Mdm2 feedback loop and G2/M phase transition process. To investigate the robustness of the regulatory network, a sensitivity analysis of kinetic parameters in the proposed mathematical model is implemented to select the most significant kinetic parameters, which are relevant to key proteins involved in G2/M phase transition. Subsequently, the statistical hypothesis testing is employed to evaluate the influence of perturbations on the G2/M regulatory network. The results indicate that G2/M regulatory network is robust to DNA damage signal when perturbations are very small that is consistent with the experimental observations. © (2014) Trans Tech Publications, Switzerland.
KW - DNA damage
KW - G2/M regulatory network
KW - Modeling
UR - https://www.scopus.com/pages/publications/84887390399
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84887390399&origin=recordpage
U2 - 10.4028/www.scientific.net/AMM.444-445.1182
DO - 10.4028/www.scientific.net/AMM.444-445.1182
M3 - RGC 32 - Refereed conference paper (with host publication)
SN - 9783037859063
VL - 444-445
T3 - Applied Mechanics and Materials
SP - 1182
EP - 1186
BT - Advances in Computational Modeling and Simulation
T2 - 2nd International Conference on Advances in Computational Modeling and Simulation, ACMS 2013
Y2 - 17 July 2013 through 19 July 2013
ER -