A programmable, fast-fixing, osteo-regenerative, biomechanically robust bone screw

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

4 Scopus Citations
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Author(s)

  • Yuanchi Zhang
  • Ruiqi Xie
  • Yuhe Yang
  • Jie Cao
  • Yunhu Tu
  • Yi Zhang
  • Tingwu Qin
  • Xin Zhao

Detail(s)

Original languageEnglish
Pages (from-to)293-305
Journal / PublicationActa Biomaterialia
Volume103
Online published17 Dec 2019
Publication statusPublished - Feb 2020
Externally publishedYes

Abstract

The use of a screw for repairing defected bones is limited by the dilemma between stiffness, bioactivity and internal fixation ability in current products. For polymer bone screw, it is difficult to achieve the bone stiffness and osteo-induction. Polymer composites may enhance bioactivity and mechanical properties but sacrifice the shape memory properties enormously. Herein, we fabricated a programmable bone screw which is composed of shape memory polyurethane, hydroxyapatite and arginylglycylaspartic acid to resolve the above problem. This composite has significantly improved mechanical and shape-memory properties with a modulus of 250 MPa, a shape fixity ratio of ~90% and a shape recovery ratio of ~96%. Moreover, shape fixity and recovery ratios of the produced SMPC screw in the simulative biological condition were respectively ~80% and ~82%. The produced screw could quickly recover to its original shape in vitro within 20 s leading to easy internal fixation. Additionally, the composite could support mesenchymal stem cell survival, proliferation and osteogenic differentiation in vitro tests. It also promoted tissue growth and showed beneficial mechanical compatibility after implantation into a rabbit femoral intracondyle for 12 weeks with little inflammation. Such bone screw exhibited a fast-fixing, tightened fitting, enhanced supporting and boosted bioactivity simultaneously in the defective bone, which provides a solution to the long-standing problem for bone repairing. We envision that our composite material will provide valuable insights into the development of a new generation of bone screws with good fixation and osteogenic properties.

Research Area(s)

  • Mechanically compatible, Osteo-inductive, Minimally invasive, Shape memory composite, Tightened fitting

Citation Format(s)

A programmable, fast-fixing, osteo-regenerative, biomechanically robust bone screw. / Zhang, Yuanchi; Hu, Jinlian; Xie, Ruiqi; Yang, Yuhe; Cao, Jie; Tu, Yunhu; Zhang, Yi; Qin, Tingwu; Zhao, Xin.

In: Acta Biomaterialia, Vol. 103, 02.2020, p. 293-305.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review