A power-free surface-tension-driven fluidic network system for large-array enzyme immobilization and glucose sensing

Fan-Gang Tseng; Kuang-Hua Lin; Hui-Ting Hsu; Yu-Hsiang Chang; Ching-Chang Chieng

doi:10.1109/MEMSYS.2003.1189775

A power-free surface-tension-driven fluidic network system for large-array enzyme immobilization and glucose sensing

Fan-Gang Tseng^*
, Kuang-Hua Lin
, Hui-Ting Hsu
, Yu-Hsiang Chang
, Ching-Chang Chieng

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

1 Citation (Scopus)

Abstract

A novel fluidic network system for batch enzyme-immobilization and glucose sensing has been proposed in this paper. This fluidic network comprises an enzyme chip for sensor and enzyme accommodation, and a fluid chip for blood sample introduction. Polymer-MEMS technologies, including SU-8 lithography and PDMS molding, have been employed for the chip fabrication. Oxygen-plasma treatment is utilized to provide channel surface hydrophilic property, which is the key for fluids driven passively without external power sources. Operated by simple sample drop-in and withdraw process, enzyme deposition can be precisely controlled in both position and amount. The dose uniformity of the enzyme deposition, better than ±10% in each sensor compartment, has been achieved by employing a H-shaped fluidic system. Functional glucose-sensor-response of 5.42 nA/mM with minim um sensible signal of 8 mM has also been demonstrated in this study. © 2003 IEEE

Original language	English
Title of host publication	Proceedings IEEE Sixteenth Annual International Conference on Micro Electro Mechanical Systems
Publisher	IEEE
Pages	419-422
ISBN (Print)	0-7803-7744-3
DOIs	https://doi.org/10.1109/MEMSYS.2003.1189775
Publication status	Published - 2003
Externally published	Yes
Event	16th Annual International Conference on Micro Electro Mechanical Systems (MEMS 2003) - Kyoto, Japan Duration: 19 Jan 2003 → 23 Jan 2003 https://ieeexplore.ieee.org/xpl/conhome/8460/proceeding

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Name
ISSN (Print)	1084-6999

Conference

Conference	16th Annual International Conference on Micro Electro Mechanical Systems (MEMS 2003)
Place	Japan
City	Kyoto
Period	19/01/03 → 23/01/03
Internet address	https://ieeexplore.ieee.org/xpl/conhome/8460/proceeding

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10.1109/MEMSYS.2003.1189775

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@inproceedings{6c5151fcf7f545fd925487aea7752cb1,

title = "A power-free surface-tension-driven fluidic network system for large-array enzyme immobilization and glucose sensing",

abstract = "A novel fluidic network system for batch enzyme-immobilization and glucose sensing has been proposed in this paper. This fluidic network comprises an enzyme chip for sensor and enzyme accommodation, and a fluid chip for blood sample introduction. Polymer-MEMS technologies, including SU-8 lithography and PDMS molding, have been employed for the chip fabrication. Oxygen-plasma treatment is utilized to provide channel surface hydrophilic property, which is the key for fluids driven passively without external power sources. Operated by simple sample drop-in and withdraw process, enzyme deposition can be precisely controlled in both position and amount. The dose uniformity of the enzyme deposition, better than ±10\% in each sensor compartment, has been achieved by employing a H-shaped fluidic system. Functional glucose-sensor-response of 5.42 nA/mM with minim um sensible signal of 8 mM has also been demonstrated in this study. {\textcopyright} 2003 IEEE",

author = "Fan-Gang Tseng and Kuang-Hua Lin and Hui-Ting Hsu and Yu-Hsiang Chang and Ching-Chang Chieng",

year = "2003",

doi = "10.1109/MEMSYS.2003.1189775",

language = "English",

isbn = "0-7803-7744-3",

publisher = "IEEE",

pages = "419--422",

booktitle = "Proceedings IEEE Sixteenth Annual International Conference on Micro Electro Mechanical Systems",

address = "United States",

note = "16th Annual International Conference on Micro Electro Mechanical Systems (MEMS 2003) ; Conference date: 19-01-2003 Through 23-01-2003",

url = "https://ieeexplore.ieee.org/xpl/conhome/8460/proceeding",

}

Tseng, F-G, Lin, K-H, Hsu, H-T, Chang, Y-H & Chieng, C-C 2003, A power-free surface-tension-driven fluidic network system for large-array enzyme immobilization and glucose sensing. in Proceedings IEEE Sixteenth Annual International Conference on Micro Electro Mechanical Systems. IEEE, pp. 419-422, 16th Annual International Conference on Micro Electro Mechanical Systems (MEMS 2003), Kyoto, Japan, 19/01/03. https://doi.org/10.1109/MEMSYS.2003.1189775

A power-free surface-tension-driven fluidic network system for large-array enzyme immobilization and glucose sensing. / Tseng, Fan-Gang; Lin, Kuang-Hua; Hsu, Hui-Ting et al.
Proceedings IEEE Sixteenth Annual International Conference on Micro Electro Mechanical Systems. IEEE, 2003. p. 419-422.

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

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T1 - A power-free surface-tension-driven fluidic network system for large-array enzyme immobilization and glucose sensing

AU - Tseng, Fan-Gang

AU - Lin, Kuang-Hua

AU - Hsu, Hui-Ting

AU - Chang, Yu-Hsiang

AU - Chieng, Ching-Chang

PY - 2003

Y1 - 2003

N2 - A novel fluidic network system for batch enzyme-immobilization and glucose sensing has been proposed in this paper. This fluidic network comprises an enzyme chip for sensor and enzyme accommodation, and a fluid chip for blood sample introduction. Polymer-MEMS technologies, including SU-8 lithography and PDMS molding, have been employed for the chip fabrication. Oxygen-plasma treatment is utilized to provide channel surface hydrophilic property, which is the key for fluids driven passively without external power sources. Operated by simple sample drop-in and withdraw process, enzyme deposition can be precisely controlled in both position and amount. The dose uniformity of the enzyme deposition, better than ±10% in each sensor compartment, has been achieved by employing a H-shaped fluidic system. Functional glucose-sensor-response of 5.42 nA/mM with minim um sensible signal of 8 mM has also been demonstrated in this study. © 2003 IEEE

AB - A novel fluidic network system for batch enzyme-immobilization and glucose sensing has been proposed in this paper. This fluidic network comprises an enzyme chip for sensor and enzyme accommodation, and a fluid chip for blood sample introduction. Polymer-MEMS technologies, including SU-8 lithography and PDMS molding, have been employed for the chip fabrication. Oxygen-plasma treatment is utilized to provide channel surface hydrophilic property, which is the key for fluids driven passively without external power sources. Operated by simple sample drop-in and withdraw process, enzyme deposition can be precisely controlled in both position and amount. The dose uniformity of the enzyme deposition, better than ±10% in each sensor compartment, has been achieved by employing a H-shaped fluidic system. Functional glucose-sensor-response of 5.42 nA/mM with minim um sensible signal of 8 mM has also been demonstrated in this study. © 2003 IEEE

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U2 - 10.1109/MEMSYS.2003.1189775

DO - 10.1109/MEMSYS.2003.1189775

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 0-7803-7744-3

SP - 419

EP - 422

BT - Proceedings IEEE Sixteenth Annual International Conference on Micro Electro Mechanical Systems

PB - IEEE

T2 - 16th Annual International Conference on Micro Electro Mechanical Systems (MEMS 2003)

Y2 - 19 January 2003 through 23 January 2003

ER -

A power-free surface-tension-driven fluidic network system for large-array enzyme immobilization and glucose sensing

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