A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

Jing-Xiang Zhang; Hongguang Li; Chi-Fai Chan; Rongfeng Lan; Wai-Lun Chan; Ga-Lai Law; Wai-Kwok Wong; Ka-Leung Wong

doi:10.1039/c2cc34963a

A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

Jing-Xiang Zhang
, Hongguang Li
, Chi-Fai Chan
, Rongfeng Lan
, Wai-Lun Chan
, Ga-Lai Law
, Wai-Kwok Wong
, Ka-Leung Wong

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

53 Citations (Scopus)

Abstract

An amphiphilic water-soluble ytterbium complex which is photo-selective, functional and Golgi apparatus specific has been designed as a responsive dual probe capable of sensitizing emission within the biological window (660 and 750 nm), generating the singlet oxygen (Φ_Δ = 0.45) and triggering local cell damage only upon exposure to visible and near-infrared laser excitation. © 2012 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	9646-9648
Journal	Chemical Communications
Volume	48
Issue number	77
DOIs	https://doi.org/10.1039/c2cc34963a
Publication status	Published - 29 Aug 2012
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

The work described in this paper was supported by grants from the HKRGC (HKBU 202210 and 202811) and HKBU (FRG2/09-10/058).

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title = "A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy",

abstract = "An amphiphilic water-soluble ytterbium complex which is photo-selective, functional and Golgi apparatus specific has been designed as a responsive dual probe capable of sensitizing emission within the biological window (660 and 750 nm), generating the singlet oxygen (ΦΔ = 0.45) and triggering local cell damage only upon exposure to visible and near-infrared laser excitation. {\textcopyright} 2012 The Royal Society of Chemistry.",

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AU - Zhang, Jing-Xiang

AU - Li, Hongguang

AU - Chan, Chi-Fai

AU - Lan, Rongfeng

AU - Chan, Wai-Lun

AU - Law, Ga-Lai

AU - Wong, Wai-Kwok

AU - Wong, Ka-Leung

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AB - An amphiphilic water-soluble ytterbium complex which is photo-selective, functional and Golgi apparatus specific has been designed as a responsive dual probe capable of sensitizing emission within the biological window (660 and 750 nm), generating the singlet oxygen (ΦΔ = 0.45) and triggering local cell damage only upon exposure to visible and near-infrared laser excitation. © 2012 The Royal Society of Chemistry.

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JO - Chemical Communications

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ER -

A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

Abstract

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