A postsynaptic role for short-term neuronal facilitation in dendritic spines
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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Detail(s)
Original language | English |
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Article number | 224 |
Journal / Publication | Frontiers in Cellular Neuroscience |
Volume | 10 |
Issue number | SEP2016 |
Publication status | Published - 30 Sep 2016 |
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DOI | DOI |
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-84991678436&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(3395e540-89c3-4127-9e53-b5e8baa564c9).html |
Abstract
Synaptic plasticity is a fundamental component of information processing in the brain. Presynaptic facilitation in response to repetitive stimuli, often referred to as pairedpulse facilitation (PPF), is a dominant form of short-term synaptic plasticity. Recently, an additional cellular mechanism for short-term facilitation, short-term postsynaptic plasticity (STPP), has been proposed. While a dendritic mechanism was described in hippocampus, its expression has not yet been demonstrated at the levels of the spine. Furthermore, it is unknown whether the mechanism can be expressed in other brain regions, such as sensory cortex. Here, we demonstrated that a postsynaptic response can be facilitated by prior spine excitation in both hippocampal and cortical neurons, using 3D digital holography and two-photon calcium imaging. The coordinated action of pre- and post-synaptic plasticity may provide a more thorough account of information processing in the brain.
Research Area(s)
- Dendritic spike, NMDA receptor, Sensory perception, Short-term synaptic plasticity, Synaptic integration
Citation Format(s)
A postsynaptic role for short-term neuronal facilitation in dendritic spines. / Yang, Sunggu; Santos, Mariton D.; Tang, Cha-Min et al.
In: Frontiers in Cellular Neuroscience, Vol. 10, No. SEP2016, 224, 30.09.2016.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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