A Portable and Dual-Button Microneedle Device Enables Intelligent Multimodal Laser Sensing

Frequent blood testing remains invasive and impractical, hindering real-time health monitoring. Interstitial fluid (ISF) offers a promising alternative, yet current microneedle platforms are complex, inefficient, and lack multiplexing capability. Here, we present a portable and dual-button microneedle device for rapid ISF sampling, coupled with multimodal laser sensing for molecular and elemental analysis. The disposable device has a low material cost (< 2 USD). The dual-button design ensures user-friendly microneedle operation, while the hollow microneedles with built-in microfluidic channels enable ISF sampling within 1 min. In parallel, gold nanocubes coupled with MXene are engineered as a sensing module, providing signal enhancement for laser spectroscopy in molecular and elemental analysis. Furthermore, artificial intelligence (AI)-assisted data processing enhances spectral data interpretation for comprehensive health assessment. Both in vitro and in vivo studies demonstrate promising performance (with accuracies exceeding 88%). This user-friendly, rapid, cost-effective, and multiplexed device offers a powerful route toward clinical translation, bridging the gap between advanced laser spectroscopy and point-of-care applications. © 2026 The Author(s). Advanced Science published by Wiley-VCH GmbH