A polydopamine-coated LAPONITE®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy

Mengxue Liu; Jiulong Zhang; Xin Li; Chao Cai; Xueyan Cao; Xiangyang Shi; Rui Guo

doi:10.1039/c9tb00398c

A polydopamine-coated LAPONITE®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy

Mengxue Liu
, Jiulong Zhang
, Xin Li
, Chao Cai
, Xueyan Cao
, Xiangyang Shi^*
, Rui Guo^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

25 Citations (Scopus)

Abstract

The development of theranostic nanoplatforms with accurate diagnosis and effective therapy performance is crucial for precision medicine applications. Herein, we developed a novel targeted theranostic nanoplatform for magnetic resonance (MR) and photoacoustic (PA) imaging-guided photothermal therapy of cancer cells overexpressing sialic acid (SA). Firstly, LAPONITE® (LAP)-stabilized Fe₃O₄ nanoparticles (NPs) with a high r₂ relaxivity were synthesized by a coprecipitation method, and then polydopamine (PDA) was coated to improve the photothermal effect and PA contrast effect, followed by the modification of PEGylated phenylboronic acid (PEG-PBA) to introduce tumor-targeting specificity into SA-overexpressed cancer cells. The formed LAP-Fe₃O₄@PDA-PEG-PBA NPs show excellent biocompatibility and photothermal conversion efficiency under near-infrared laser irradiation and are able to be used for dual modal MR/PA imaging of a xenografted tumor model and induce complete eradication of tumors after NIR laser treatment. In summary, LAP-Fe₃O₄@PDA-PEG-PBA NPs could be theranostic nanoplatforms for sensitive MR/PA imaging and effective photothermal therapy of SA-overexpressed tumors.

© The Royal Society of Chemistry 2019

Original language	English
Pages (from-to)	3856-3864
Number of pages	9
Journal	Journal of Materials Chemistry B
Volume	7
Issue number	24
Online published	30 May 2019
DOIs	https://doi.org/10.1039/c9tb00398c
Publication status	Published - 28 Jun 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

Funding

This study is financially supported by the Shanghai Natural Science Foundation (17ZR1401200), and the National Natural Science Foundation of China (21785031 and 81761148028).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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title = "A polydopamine-coated LAPONITE{\textregistered}-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy",

abstract = "The development of theranostic nanoplatforms with accurate diagnosis and effective therapy performance is crucial for precision medicine applications. Herein, we developed a novel targeted theranostic nanoplatform for magnetic resonance (MR) and photoacoustic (PA) imaging-guided photothermal therapy of cancer cells overexpressing sialic acid (SA). Firstly, LAPONITE{\textregistered} (LAP)-stabilized Fe3O4 nanoparticles (NPs) with a high r2 relaxivity were synthesized by a coprecipitation method, and then polydopamine (PDA) was coated to improve the photothermal effect and PA contrast effect, followed by the modification of PEGylated phenylboronic acid (PEG-PBA) to introduce tumor-targeting specificity into SA-overexpressed cancer cells. The formed LAP-Fe3O4@PDA-PEG-PBA NPs show excellent biocompatibility and photothermal conversion efficiency under near-infrared laser irradiation and are able to be used for dual modal MR/PA imaging of a xenografted tumor model and induce complete eradication of tumors after NIR laser treatment. In summary, LAP-Fe3O4@PDA-PEG-PBA NPs could be theranostic nanoplatforms for sensitive MR/PA imaging and effective photothermal therapy of SA-overexpressed tumors. {\textcopyright} The Royal Society of Chemistry 2019",

author = "Mengxue Liu and Jiulong Zhang and Xin Li and Chao Cai and Xueyan Cao and Xiangyang Shi and Rui Guo",

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doi = "10.1039/c9tb00398c",

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A polydopamine-coated LAPONITE®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy. / Liu, Mengxue; Zhang, Jiulong; Li, Xin et al.
In: Journal of Materials Chemistry B, Vol. 7, No. 24, 28.06.2019, p. 3856-3864.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - A polydopamine-coated LAPONITE®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy

AU - Liu, Mengxue

AU - Zhang, Jiulong

AU - Li, Xin

AU - Cai, Chao

AU - Cao, Xueyan

AU - Shi, Xiangyang

AU - Guo, Rui

PY - 2019/6/28

Y1 - 2019/6/28

N2 - The development of theranostic nanoplatforms with accurate diagnosis and effective therapy performance is crucial for precision medicine applications. Herein, we developed a novel targeted theranostic nanoplatform for magnetic resonance (MR) and photoacoustic (PA) imaging-guided photothermal therapy of cancer cells overexpressing sialic acid (SA). Firstly, LAPONITE® (LAP)-stabilized Fe3O4 nanoparticles (NPs) with a high r2 relaxivity were synthesized by a coprecipitation method, and then polydopamine (PDA) was coated to improve the photothermal effect and PA contrast effect, followed by the modification of PEGylated phenylboronic acid (PEG-PBA) to introduce tumor-targeting specificity into SA-overexpressed cancer cells. The formed LAP-Fe3O4@PDA-PEG-PBA NPs show excellent biocompatibility and photothermal conversion efficiency under near-infrared laser irradiation and are able to be used for dual modal MR/PA imaging of a xenografted tumor model and induce complete eradication of tumors after NIR laser treatment. In summary, LAP-Fe3O4@PDA-PEG-PBA NPs could be theranostic nanoplatforms for sensitive MR/PA imaging and effective photothermal therapy of SA-overexpressed tumors. © The Royal Society of Chemistry 2019

AB - The development of theranostic nanoplatforms with accurate diagnosis and effective therapy performance is crucial for precision medicine applications. Herein, we developed a novel targeted theranostic nanoplatform for magnetic resonance (MR) and photoacoustic (PA) imaging-guided photothermal therapy of cancer cells overexpressing sialic acid (SA). Firstly, LAPONITE® (LAP)-stabilized Fe3O4 nanoparticles (NPs) with a high r2 relaxivity were synthesized by a coprecipitation method, and then polydopamine (PDA) was coated to improve the photothermal effect and PA contrast effect, followed by the modification of PEGylated phenylboronic acid (PEG-PBA) to introduce tumor-targeting specificity into SA-overexpressed cancer cells. The formed LAP-Fe3O4@PDA-PEG-PBA NPs show excellent biocompatibility and photothermal conversion efficiency under near-infrared laser irradiation and are able to be used for dual modal MR/PA imaging of a xenografted tumor model and induce complete eradication of tumors after NIR laser treatment. In summary, LAP-Fe3O4@PDA-PEG-PBA NPs could be theranostic nanoplatforms for sensitive MR/PA imaging and effective photothermal therapy of SA-overexpressed tumors. © The Royal Society of Chemistry 2019

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SN - 2050-750X

VL - 7

SP - 3856

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JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 24

ER -

A polydopamine-coated LAPONITE®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy

Abstract

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Funding

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Erratum: A polydopamine-coated LAPONITE^®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy

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A polydopamine-coated LAPONITE®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy

Abstract

Bibliographical note

Funding

UN SDGs

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Research output

Erratum: A polydopamine-coated LAPONITE®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy

Cite this

Erratum: A polydopamine-coated LAPONITE^®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy