A platinum-based fluorescent "turn on" sensor to decipher the reduction of platinum(iv) prodrugs

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

6 Scopus Citations
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Detail(s)

Original languageEnglish
Pages (from-to)5394-5398
Journal / PublicationDalton Transactions
Volume51
Issue number14
Online published25 Feb 2022
Publication statusPublished - 14 Apr 2022

Abstract

We report a strategy to use a fluorescence "turn on" sensor to quantify the reduction of platinum(iv) prodrugs in a real-time mode by simply and conveniently monitoring the fluorescence intensity. Proteins with high molecular weights, especially those between 10 and 100 kDa, contribute more to the reduction of the platinum(iv) complex in cell extracts.

Research Area(s)

  • MECHANISM, DELIVERY, KINETICS, DESIGN, PROBES