A Photoinduced Nonadiabatic Decay-Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Jen-Shyang Ni
  • Xun Zhang
  • Guang Yang
  • Tianyi Kang
  • Xiangwei Lin
  • Menglei Zha
  • Yaxi Li
  • Kai Li

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)11298-11302
Journal / PublicationAngewandte Chemie - International Edition
Volume59
Issue number28
Online published13 Apr 2020
Publication statusPublished - 6 Jul 2020

Abstract

It remains highly challenging to identify small molecule-based photothermal agents with a high photothermal conversion efficiency (PTCE). Herein, we adopt a double bond-based molecular motor concept to develop a new class of small photothermal agents to break the current design bottleneck. As the double-bond is twisted by strong twisted intramolecular charge transfer (TICT) upon irradiation, the excited agents can deactivate non-radiatively through the conical intersection (CI) of internal conversion, which is called photoinduced nonadiabatic decay. Such agents possess a high PTCE of 90.0 %, facilitating low-temperature photothermal therapy in the presence of a heat shock protein 70 inhibitor. In addition, the behavior and mechanism of NIR laser-triggered molecular motions for generating heat through the CI pathway have been further understood through theoretical and experimental evidence, providing a design principle for highly efficient photothermal and photoacoustic agents.

Research Area(s)

  • conical intersections, heat shock protein 70, imines, NIR agents, photothermal therapy

Citation Format(s)

A Photoinduced Nonadiabatic Decay-Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy. / Ni, Jen-Shyang; Zhang, Xun; Yang, Guang et al.
In: Angewandte Chemie - International Edition, Vol. 59, No. 28, 06.07.2020, p. 11298-11302.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review