A phosphorescent rhenium(I) tricarbonyl polypyridine complex appended with a fructose pendant that exhibits photocytotoxicity and enhanced uptake by breast cancer cells

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Pages (from-to)5098-5102
Journal / PublicationOrganometallics
Volume32
Issue number18
Publication statusPublished - 23 Sept 2013

Abstract

We demonstrated that the cytotoxicity of a phosphorescent rhenium(I) polypyridine complex with a fructose pendant was enhanced upon irradiation and the cellular uptake of the complex was mediated by fructose transporters and inhibited by unmodified fructose but was independent of glucose-specific transporters. This complex has been used to image breast cancer cells, where fructose transporters are overexpressed. © 2013 American Chemical Society.

Citation Format(s)

A phosphorescent rhenium(I) tricarbonyl polypyridine complex appended with a fructose pendant that exhibits photocytotoxicity and enhanced uptake by breast cancer cells. / Yin Zhang, Kenneth; Ka-Shun Tso, Karson; Louie, Man-Wai et al.
In: Organometallics, Vol. 32, No. 18, 23.09.2013, p. 5098-5102.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review